AI Article Synopsis
- The study investigates the role of discoidin domain receptor 1 (DDR1) in human melanoma, noting its high expression in melanoma cases and its link to worse patient outcomes.
- High DDR1 levels are associated with specific clinical factors like Clark level, ulceration, and BRAF mutations in melanoma patients.
- Reducing DDR1 expression through techniques like siRNA inhibited melanoma cell growth and movement, while a DDR1 inhibitor showed promise in decreasing melanoma cell proliferation in lab settings and tumor models.
Article Abstract
The discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase family that signals in response to collagen and that has been implicated in cancer progression. In the present study, we investigated the expression and role of DDR1 in human melanoma progression. Immunohistochemical staining of human melanoma specimens (n = 52) shows high DDR1 expression in melanoma lesions that correlates with poor prognosis. DDR1 expression was associated with the clinical characteristics of Clark level and ulceration and with BRAF mutations. Downregulation of DDR1 by small interfering RNA (siRNA) in vitro inhibited melanoma cells malignant properties, migration, invasion, and survival in several human melanoma cell lines. A DDR tyrosine kinase inhibitor (DDR1-IN-1) significantly inhibited melanoma cell proliferation in vitro, and ex vivo and in tumor xenografts, underlining the promising potential of DDR1 inhibition in melanoma.
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| http://dx.doi.org/10.1111/pcmr.12809 | DOI Listing |
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