AI Article Synopsis
- Diabetes mellitus (DM) increases the likelihood of developing pulmonary tuberculosis (TB) and can lead to negative treatment results.
- A study measuring cytokines in patients with TB and DM revealed that those with DM exhibited persistent hyper-inflammation throughout TB treatment.
- The ongoing inflammation in individuals with TB and DM may lead to long-term issues, such as recurrent TB and harmful immune system problems.
Article Abstract
Diabetes mellitus (DM) increases risk for pulmonary tuberculosis (TB) and adverse treatment outcomes. Systemic hyper-inflammation is characteristic in people with TB and concurrent DM (TBDM) at baseline, but the impact of TB treatment on this pattern has not been determined. We measured 17 plasma cytokines and growth factors in longitudinal cohorts of Indian and Brazilian pulmonary TB patients with or without DM. Principal component analysis revealed virtually complete separation of TBDM from TB individuals in both cohorts at baseline, with hyper-inflammation in TBDM that continued through treatment completion at six months. By one year after treatment completion, there was substantial convergence of mediator levels between groups within the India cohort. Non-resolving systemic inflammation in TBDM comorbidity could reflect delayed lesion sterilization or non-resolving sterile inflammation. Either mechanism portends unfavorable long-term outcomes including risk for recurrent TB and for damaging immune pathology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660216 | PMC |
| http://dx.doi.org/10.7554/eLife.46477 | DOI Listing |
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