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MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.
Nucleic Acids Res
January 2025
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.
View Article and Find Full Text PDFGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Nat Genet
May 2024
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Article Synopsis
- PTSD genetics have been difficult to study compared to other psychiatric disorders, limiting our biological understanding of the condition.
- A large-scale meta-analysis involving over 1.2 million individuals identified 95 genome-wide significant loci, with 80 being new discoveries related to PTSD.
- Researchers identified 43 potential causal genes linked to neurotransmitter activity, developmental processes, synaptic function, and immune regulation, enhancing our knowledge of the neurobiological systems involved in PTSD.
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment.
Environ Int
April 2024
RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic. Electronic address:
The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies.
View Article and Find Full Text PDFDepression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.
Nat Med
July 2023
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Article Synopsis
- Depression is a prevalent psychiatric disorder and major global disability, and a study involving over 1.3 million people identified 243 genetic risk loci, with 64 being newly discovered, many linked to glutamate and GABA receptor genes targeted by antidepressant medications.
- The research showed depression is highly polygenic, meaning it's influenced by many genetic variants, with about 11,700 variants accounting for 90% of heritability; many of these variants also affect other psychiatric disorders and educational outcomes.
- The study highlighted genetic and clinical differences within depression subgroups, indicating those with a higher polygenic burden face significantly increased risks for recurrence and other mental health issues, with notable differences based on sex.
An immunogenetic investigation of 30 autoimmune and autoinflammatory diseases and their links to psychiatric disorders in a nationwide sample.
Immunology
April 2023
CORE-Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
Article Synopsis
- * Utilizing a large Danish sample (65,534 individuals), researchers conducted statistical analyses to link certain genetic markers (HLA alleles) to 30 different AIIDs and assessed their connection to psychiatric disorders.
- * Results revealed significant associations between specific AIIDs and psychiatric diagnoses, as well as numerous genetic links between HLA alleles and these diseases, underscoring the intertwined nature of autoimmune conditions and mental health.
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