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The Role of Epithelial-Mesenchymal Transition in Osteosarcoma Progression: From Biology to Therapy.
Diagnostics (Basel)
March 2025
Department of Morphofunctional Sciences I-Pathology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Osteosarcoma (OS) is the most common primary malignant bone tumor, predominantly affecting children, adolescents, and young adults. Epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose their cell-cell adhesion and gain migratory and invasive properties, has been extensively studied in various carcinomas. However, its role in mesenchymal tumors like osteosarcoma remains less explored.
View Article and Find Full Text PDFMacroscopically Self-Aligned and Chiralized Carbon Nanotubes: From Filtration to Innovation.
ACS Nano
March 2025
Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston,, Texas 77005, United States.
Because of their natural 1D structure combined with intricate chiral variations, carbon nanotubes (CNTs) exhibit various exceptional physical properties, such as ultrahigh thermal conductivity and diameter-dependent electrical behavior, ranging from semiconducting to metallic. While CNTs excel individually at the nanoscale, their 1D and chiral nature can be lost on a macroscopic scale when they are randomly assembled. Therefore, the alignment and organization of CNTs in macroscopic structures is crucial for harnessing their full potential.
View Article and Find Full Text PDFpH-Activated NIR fluorescent probe for sensitive mitochondrial viscosity detection.
Org Biomol Chem
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Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, China.
Understanding mitochondrial viscosity is crucial for comprehending cellular health and function. Therefore, accurate and sensitive measurement of mitochondrial viscosity is essential for advancing medical diagnostics and treatment strategies. In this study, a novel near-infrared (NIR) fluorescent probe SSN was developed, based on the dual mechanisms of Excited-State Intramolecular Proton Transfer (ESIPT) and Twisted Intramolecular Charge Transfer (TICT).
View Article and Find Full Text PDFUnveiling Rarity: Giant Septal Coronary Vein Dissection, an Unforeseen Twist in Complications of Left Bundle Branch Area Pacing.
J Innov Card Rhythm Manag
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Division of Cardiac Electrophysiology, University of Michigan Health Care, Ann Arbor, MI, USA.
Left bundle branch area pacing (LBBAP) is a promising pacing technique aimed at mitigating pacing-induced cardiomyopathy; however, a gap in understanding persists concerning intraprocedural complications and their management. This case study sheds light on a rare complication associated with LBBAP. Through sheath penetration into the interventricular septum at a typical site, a septogram revealed the dissection of a large septal coronary vein.
View Article and Find Full Text PDFState-dependent motion of a genetically encoded fluorescent biosensor.
Proc Natl Acad Sci U S A
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Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
Genetically encoded biosensors can measure biochemical properties such as small-molecule concentrations with single-cell resolution, even in vivo. Despite their utility, these sensors are "black boxes": Very little is known about the structures of their low- and high-fluorescence states or what features are required to transition between them. We used LiLac, a lactate biosensor with a quantitative fluorescence-lifetime readout, as a model system to address these questions.
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