Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in this setting.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613811PMC
http://dx.doi.org/10.1126/scitranslmed.aat0360DOI Listing

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