Introduction: There are no validated, practical, and quantitative measures of disease severity in Lambert-Eaton myasthenia (LEM).
Methods: Data from the Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome (DAPPER) trial were analyzed to assess triple timed up-and-go (3TUG) reproducibility and relationships between 3TUG times and other measures of LEM severity.
Results: The coverage probability technique showed ≥0.90 probability for an acceptable 3TUG difference of ≤0.2, indicating that it is reproducible in LEM patients. The correlation between 3TUG times and lower extremity function scores was significant in subjects who continued and in those who were withdrawn from 3,4-diaminopyridine free base. Worsening patient-reported Weakness Self-Assessment Scale and Investigator Assessment of Treatment Effect scores corresponded with prolongation of 3TUG times.
Discussion: The 3TUG is reproducible, demonstrates construct validity for assessment of lower extremity function in LEM patients, and correlates with changes in patient and physician assessments. These findings, along with prior reliability studies, indicate 3TUG is a valid measure of disease severity in LEM.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357813 | PMC |
| http://dx.doi.org/10.1002/mus.26625 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Clinical Significance of Using PASS Thresholds When Administering Patient-Reported Outcome Instruments After Anterior Cruciate Ligament Reconstruction.
Am J Sports Med
January 2025
University of Kentucky, Department of Athletic Training and Clinical Nutrition, Lexington, Kentucky, USA.
Background: Patient-reported outcome (PROs) instruments of knee function quality of life are routinely administered to patients after anterior cruciate ligament reconstruction (ACLR). The Patient Acceptable Symptom State (PASS), an evidence-based threshold defining perceived outcomes, may be a useful indicator of strength and functional performance.
Purpose: To compare strength and functional performance between patients recovering from ACLR who did and did not meet PASS thresholds on associated PROs.
ImpENSA eHealthy Conversation Skills training for healthcare professionals aimed at improving micronutrient status during the first 1000 days in South Africa.
PLOS Glob Public Health
December 2024
Department of Paediatrics, Dr. von Hauner Children's Hospital, LMU-Ludwig Maximilians Universität Munich, Munich, Germany.
Individuals' lifestyle behaviours determine health. Improving Early Nutrition and Health in South Africa ("ImpENSA"), an EU Erasmus+ co-funded project, aims to tackle the triple burden of malnutrition in South Africa through equipping healthcare professionals (HCPs) with knowledge and skills to effectively support healthy nutritional choices among pregnant women and mothers/infant caregivers. Healthy Conversation Skills (HCS) is a behaviour change intervention utilising open discovery questions, active listening, reflection on practice and goal-setting support through SMARTER (Specific, Measured, Action-oriented, Realistic, Timed, Evaluated and Reviewed) planning as core competences.
View Article and Find Full Text PDFSex-based differences in physical and psychological recovery, and return to sport, following anterior cruciate ligament reconstruction.
Knee
January 2025
School of Human Sciences (Exercise and Sport Science), University of Western Australia, Perth, Western Australia; Orthopaedic Research Foundation of Western Australia, Perth, Western Australia; Perth Orthopaedic & Sports Medicine Research Institute, Perth, Western Australia; HFRC, Perth, Western Australia. Electronic address:
Article Synopsis
- - This study examined differences in recovery between males and females after anterior cruciate ligament reconstruction (ACLR) focusing on physical and psychological aspects as well as return to sport (RTS) rates.
- - Results showed that males had better recovery scores on measures like the ACL-RSI and the IKDC, with a higher percentage returning to pivoting sports compared to females at 24 months post-operation.
- - Overall, females exhibited lower physical performance, subjective function, and psychological readiness for RTS, highlighting a need for tailored recovery strategies based on sex.
Background: Advanced neuromuscular training prepares patients with anterior cruciate ligament reconstruction (ACLR) for sport participation. Return-to-sport testing often includes single-leg hop tests, yet combining motor and cognitive tasks (i.e.
View Article and Find Full Text PDFClinical characteristics, use and switch of drugs for obstructive airway diseases among patients with COPD experiencing an exacerbation: a retrospective analysis of Italian administrative healthcare data.
BMC Pulm Med
October 2024
Fondazione Ricerca e Salute (ReS) - Research and Health Foundation, Via Dei Due Macelli 48, Rome, Italy.
Background: Chronic obstructive pulmonary disease (COPD) represents an important health challenge, despite being preventable and manageable thanks to up-to-date recommendations. In Italy, the pharmaceutical care of COPD patients is still ill-timed and inaccurate. This study aimed to describe the treatment of COPD patients in Italy and possible switches following an exacerbation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!