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Comparison of the incidence of proteinuria and changes in eGFR among febuxostat and topiroxostat users.
Clin Exp Nephrol
January 2025
Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Background: Febuxostat and topiroxostat are non-purine selective xanthine oxidoreductase inhibitors commonly used for hyperuricaemia treatment in Japan. However, comparative data on the effects of febuxostat and topiroxostat on renal function and proteinuria are limited. This study compared proteinuria incidence and changes in the estimated glomerular filtration rate (eGFR) among prevalent febuxostat and topiroxostat users.
View Article and Find Full Text PDFSwarm systems as a platform for open-ended evolutionary dynamics.
Philos Trans A Math Phys Eng Sci
January 2025
Binghamton Center of Complex Systems, Binghamton University, State University of New York, Binghamton, NY 13902, USA.
Artificial swarm systems have been extensively studied and used in computer science, robotics, engineering and other technological fields, primarily as a platform for implementing robust distributed systems to achieve pre-defined objectives. However, such swarm systems, especially heterogeneous ones, can also be utilized as an ideal platform for creating open-ended evolutionary dynamics that do not converge toward pre-defined goals but keep exploring diverse possibilities and generating novel outputs indefinitely. In this article, we review Swarm Chemistry and its variants as concrete sample cases to illustrate beneficial characteristics of heterogeneous swarm systems, including the cardinality leap of design spaces, multi-scale structures/behaviours and their diversity, and robust self-organization, self-repair and ecological interactions of emergent patterns, all of which serve as the driving forces for open-ended evolutionary processes.
View Article and Find Full Text PDFJuhn Atushi Wada (1924-2023) and the history of the Wada test.
J Clin Neurosci
January 2025
Department of Neurology, Northwell Health, New Hyde Park, NY, USA. Electronic address:
Epilepsy is one of the most common neurologic conditions in the world. Surgical treatment for refractoryepilepsy is a method to optimize the quality of life for patients. Throughout his medical career, Dr.
View Article and Find Full Text PDFPostoperative symptom changes following uterine artery embolization for uterine fibroid based on FIGO classification.
CVIR Endovasc
January 2025
Department of Radiology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.
Background: Classifying uterine fibroid using the International Federation of Gynecology and Obstetrics (FIGO) classification system assists treatment decision-making and planning. This study aimed to study whether different fibroid locations influence clinical outcomes following uterine artery embolization (UAE).
Methods: This is a retrospective cohort study of patients who underwent UAE for symptomatic uterine fibroid between December 2016 and January 2023 at our hospital.
Management of nausea and vomiting induced by antibody-drug conjugates.
Breast Cancer
January 2025
Advanced Cancer Translational Research Institute, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Antibody-drug conjugates (ADCs) are an emerging class of anticancer therapy that combines the specificity and long circulation half-life of monoclonal antibodies with the cytotoxic potency of the payload connected through a chemical linker. The optimal management of toxicities is crucial for improving quality of life in patients undergoing ADCs and for avoiding improper dose reductions or discontinuations. This article focuses on the characteristics and management of nausea and vomiting (NV) induced by three ADCs: trastuzumab deruxtecan (T-DXd), sacituzumab govitecan (SG), and datopotamab deruxtecan (Dato-DXd).
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