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[Safety and efficacy assessments using human iPS cell-derived cardiomyocytes].
Nihon Yakurigaku Zasshi
January 2025
The delay and loss of drugs are serious problems in Japan. To overcome this issue, it is important to strengthen drug development capabilities. For drug development, the establishment and advancement of non-clinical testing methods are necessary for safe and effective clinical trials.
View Article and Find Full Text PDFQuantifying non-clinical outcomes of ultra-hypofractionated breast radiotherapy in Western NSW-A narrative review.
J Med Radiat Sci
December 2024
Central West Cancer Centre, Orange Health Service, Orange, New South Wales, Australia.
Ultra-Hypofractionated Whole Breast Radiotherapy (U-WBRT) has been proven to be a viable treatment option for breast cancer patients receiving radiation therapy, however, due to its novelty our understanding of its non-clinical benefits is still evolving. With increasing U-WBRT selection during COVID and in rural and regional settings such as the Western New South Wales Local Health District (WNSWLHD), it's important to quantify the savings when compared to other fractionation schedules (e.g.
View Article and Find Full Text PDFElectrochemotherapy in the Locoregional Treatment of Metastatic Colorectal Liver Metastases: A Systematic Review.
Curr Oncol
November 2024
Department of Diagnostic Imaging and Oncologic Radiotherapy-Emergency and Interventional Radiology Unit, Fondazione Policlinico Universitario "Agostino Gemelli"-IRCCS, 00168 Rome, Italy.
Background: The global incidence of secondary liver cancer is rising due to multiple risk factors, presenting significant challenges in public health. Similarly, colorectal cancer (CRC) remains a leading cause of cancer-related mortality with the development of frequent liver metastases. Surgical resection of CRC liver metastases is only suitable for a limited subset of patients, necessitating alternative nonsurgical treatments such as electrochemotherapy (ECT); Methods: This review adhered to the S.
View Article and Find Full Text PDFDesign of multi-modal antenna arrays for microwave hyperthermia and 1H/1⁹F MRI monitoring of drug release.
PLoS One
October 2024
Department of Biomedical Engineering, Gachon University, Seongnam, South Korea.
This simulation-based study presented a novel hybrid RF antenna array designed for neck cancer treatment within a 7T MRI system. The proposed design aimed to provide microwave hyperthermia to release 19F-labeled anticancer drugs from thermosensitive liposomes, facilitating drug concentration monitoring through 19F imaging and enabling 1H anatomical imaging and MR thermometry for temperature control. The design featured a bidirectional microstrip for generating the magnetic |B1|-fields required for 1H and 19F MR imaging, along with a patch antenna for localized RF heating.
View Article and Find Full Text PDFExacerbation of paranoia-like thoughts following exposure to common misophonia trigger sounds.
Schizophr Res
December 2024
Experimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland.
Paranoia-like thoughts refer to heightened suspicions and unfounded beliefs about being watched or persecuted by others. Recent research has found a significant correlation between misophonia symptoms, a form of decreased sound tolerance, and paranoia-like thoughts, both of which are linked to heightened negative emotions in clinical and non-clinical populations. Notably, it has been observed that misophonia may also be associated with the tendency to attribute hostile intent to those producing triggering sounds, a feature consistent with paranoid ideation (i.
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