Salpratlactones A () and B (), a pair of abietane - tautomers from , were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, and were featured by unique 6/5 carbocyclic rings bearing a γ-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 μM potently and equally increased Ca3.1 TTCC peak currents, and had an EC value of 12.48 μM.
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Salpratlactones A and B: A Pair of - Tautomeric Abietanes as Ca3.1 T-Type Calcium Channel Agonists from .
Org Lett
July 2019
State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.
Salpratlactones A () and B (), a pair of abietane - tautomers from , were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, and were featured by unique 6/5 carbocyclic rings bearing a γ-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 μM potently and equally increased Ca3.
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