AI Article Synopsis
- The study focuses on the role of circular RNAs (circRNAs) in regulating gene expression through their interactions with various miRNAs.
- The ACT (Analysis of Common Targets) tool was developed to make it easier to identify which genes are likely to be influenced by circRNAs, considering the complex interactions among multiple miRNAs.
- The tool is accessible online for free and helps researchers pinpoint circRNA-regulated genes and their related biological pathways for further research.
Article Abstract
Background: The studies of functions of circular RNAs (circRNAs) are heavily focused on the regulation of gene expression through interactions with multiple miRNAs. However, the number of predicted target genes is typically overwhelming due to the synergistic complexity caused by two factors ─ the binding of multiple miRNAs to a circRNA and the existence of multiple targets for each miRNA. Analysis of common targets (ACT) was designed to facilitate the identification of potential circRNA targets.
Results: We demonstrated the feasibility of the proposed feature/measurement to assess which genes are more likely to be regulated by circRNAs with given sequences by calculating the level of co-regulation by multiple miRNAs. The web service is made freely available at http://lab-x-omics.nchu.edu.tw/ACT_Server .
Conclusions: ACT allows users to identify potential circRNA-regulated genes and their associated pathways for further investigation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607602 | PMC |
| http://dx.doi.org/10.1186/s12859-019-2966-3 | DOI Listing |
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