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An intron-split microRNA mediates cleavage of the mRNA encoded by low phosphate root in Solanaceae.
Planta
January 2025
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.
A microRNA with a non-canonical precursor structure harbours an intron in between its miRNA-5p and miRNA-3p relevant for its biogenesis, is conserved across Solanaceae, and targets the mRNA of low phosphate root. Hundreds of miRNAs have been identified in plants and great advances have been accomplished in the understanding of plant miRNA biogenesis, mechanisms and functions. Still, many miRNAs, particularly those with less conventional features, remain to be discovered.
View Article and Find Full Text PDFIdentification of Stable Reference miRNAs for miRNA Expression Analysis in Adult Neurogenesis Across Mouse and Human Tissues.
Cells
December 2024
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Accurate normalization in miRNA studies requires the use of appropriate endogenous controls, which can vary significantly depending on cell types, treatments, and physiological or pathological conditions. This study aimed to identify suitable endogenous miRNA controls for neural progenitor cells (NPCs) and hippocampal tissues, both of which play crucial roles in neurogenesis. Using small RNA sequencing, we identified the most stable miRNAs in primary mouse NPCs and hippocampal tissues and accessed their stability using NormFinder analysis.
View Article and Find Full Text PDFSecretome - the role of extracellular vesicles in the pathogenesis and therapy of neurodegenerative diseases.
Postep Psychiatr Neurol
September 2024
Lazarski University, Faculty of Medicine, Warsaw, Poland.
Purpose: Extracellular vesicles are the subject of many studies in various medical specialties. Their role in neurodegenerative diseases is increasing and they worth introducing in more detail.
Methods: This review was performed following an electronic search of the database PubMed/Medline and Web of Science for English-language articles between 2010 and 2024 in the fields of medicine, molecular biology, and biochemistry.
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation.
Immun Ageing
November 2024
Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Article Synopsis
- miR-146a regulates inflammation and is involved in high-fat diet-induced hypothalamic senescence, but its role has not been fully explored.
- Wild-type mice on a high-fat diet showed increased body weight, cognitive decline, and senescence markers in the brain, while knocking out miR-146a exacerbated these effects.
- Treatment with elocalcitol improved health outcomes in HFD WT mice by upregulating miR-146a and mitigating senescence effects, highlighting its therapeutic potential, which was not effective in miR-146a knockout mice.
The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development.
Development
November 2024
Laboratory of Developmental Cell Biology and Disease, State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Article Synopsis
- Ednrb is essential for the early proliferation of melanoblasts, particularly in skin and eye development.
- Through RNA-sequencing, it was discovered that the gene Aim2 is upregulated in cells lacking Ednrb, and its knockdown can partially restore melanoblast proliferation.
- The research highlights a regulatory pathway involving Ednrb, Aim2, and microRNA miR-196b, indicating that Ednrb signaling negatively regulates Aim2 to promote melanocyte development.
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