Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies.

Nutrients

Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Street, 050663 Bucharest, Romania.

Published: June 2019

AI Article Synopsis

  • Cerebrovascular accidents (strokes) are a leading cause of death and disability worldwide, prompting the WHO to develop stroke prevention guidelines.
  • There are numerous studies highlighting the health benefits of anthocyanin (ACN) consumption, but a comprehensive analysis linking ACNs specifically to stroke prevention is lacking.
  • This review aims to summarize existing research on ACN-rich diets and supplements, exploring their potential role in stroke prevention and how they may affect the brain based on pharmacokinetic findings.

Article Abstract

Cerebrovascular accidents are currently the second major cause of death and the third leading cause of disability in the world, according to the World Health Organization (WHO), which has provided protocols for stroke prevention. Although there is a multitude of studies on the health benefits associated with anthocyanin (ACN) consumption, there is no a rigorous systematization of the data linking dietary ACN with stroke prevention. This review is intended to present data from epidemiological, , , and clinical studies dealing with the stroke related to ACN-rich diets or ACN supplements, along with possible mechanisms of action revealed by pharmacokinetic studies, including ACN passage through the blood-brain barrier (BBB).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682894PMC
http://dx.doi.org/10.3390/nu11071479DOI Listing

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