AI Article Synopsis
- Protein C and protein S are important anti-coagulant proteins that help prevent blood clots by inhibiting activated proteins involved in clotting.
- Inherited deficiencies in these proteins can lead to hypercoagulability, significantly increasing the risk of thromboembolism, such as venous thromboembolism or pulmonary embolism.
- This case study highlights a young male with both protein C and S deficiencies who unexpectedly experienced a myocardial infarction, resulting in worsened heart function and dilated cardiomyopathy.
Article Abstract
Protein C and protein S are vitamin K dependent anti-coagulant proteins required for the inhibition of activated protein V and VIII. In an inherited thrombophilia, hypercoagulability caused by the deficiency of protein C and protein S predisposes an individual to increased risk of thromboembolism (TE) that could herald as a venous thromboemboilsm (VTE) in the leg, pulmonary embolism (PE), stroke, or Budd-Chiari syndrome. However, very rarely does inherited thrombophilia cause coronary artery thrombosis leading to the development of myocardial infarction (MI). We report a case of a young male with combined protein C and protein S deficiency who presented with acute MI, worsened ventricular systolic function, and progressive declination of ejection fraction (EF) secondary to dilated cardiomyopathy (DCM).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581329 | PMC |
| http://dx.doi.org/10.7759/cureus.4492 | DOI Listing |
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