AI Article Synopsis
- Pharmacovigilance studies focus on the effects of prescription drugs on pregnant and lactating women, helping to identify risks like teratogenic effects.
- The study used data from a nationwide claims dataset to analyze prescription drug trends among pregnant women from 2010 to 2014, revealing a significant rise in the use of opioids, antidepressants, antihypertensives, and antidiabetics.
- Key findings showed specific prescriptions, such as hydrocodone and sertraline, were prevalent, and the research emphasized the importance of data visualization for understanding drug use patterns during pregnancy and lactation.
Article Abstract
Background: Pharmacovigilance studies for the pregnancy population are an important tool to address the teratogenic and maternal effects of prescription drugs.
Objectives: We sought to leverage existing data to provide empirical evidence that reflects current drug utilization by pregnant/lactating women for pharmacovigilance and effective study designs.
Methods: Temporal patterns of prescription drug use during pregnancy and lactation for four clinical conditions were visualized using a R package and an administrative claims dataset representing nationwide privately-insured women.
Results: During the years 2010 to 2014, there was a significant increase (p < 0.001) in overall use of opioid, antidepressant, antihypertensive, and antidiabetic prescriptions. Hydrocodone, sertraline, labetalol, and metformin were the most common prescriptions for perinatal use in its respective category. Trimester-specific prescription patterns were reported.
Conclusions: Visualization of administrative claims data can quickly detect temporal patterns of prescription drug use during pregnancy and lactation.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568088 | PMC |
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