AI Article Synopsis
- Ewing's sarcoma is the second most common malignant bone tumor but is rare in young children, especially neonates and infants, often leading to misdiagnoses.
- This report highlights a case of a 4-month-old girl with soft-tissue Ewing's sarcoma that was mistaken for a benign neck mass across various evaluation methods.
- The study also reviews guidelines regarding the timing of biopsies for neck masses in children, emphasizing the need for careful diagnosis in similar clinical scenarios.
Article Abstract
Despite being the second most common malignant bone tumor, Ewing's sarcoma remains uncommon in younger children and seldom seen in neonates and infants. Extraskeletal locations are even rarer, hardly ever suspected, and often misdiagnosed, causing delays in management. The histologic similarities of Ewing's sarcoma to more common pediatric small-blue-round-cell tumors such as lymphoma and neuroblastoma necessitate immunohistochemistry and molecular genetics for clinching the diagnosis. We report a soft-tissue Ewing's sarcoma in a 4-month-old female infant masquerading as a benign neck mass clinically, radiologically, cytologically, and intraoperatively. We also reviewed literature for any existing guidelines on when to biopsy neck masses in the pediatric population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568164 | PMC |
| http://dx.doi.org/10.4103/jiaps.JIAPS_98_18 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Primary intracranial extraosseous Ewing's sarcoma with intraspinal metastasis in children: illustrative case.
J Neurosurg Case Lessons
January 2025
Department of Neurosurgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: The diagnosis of intracranial extraosseous Ewing's sarcoma (EES) poses challenges due to the absence of specific clinical and imaging features prior to surgery. It is crucial to differentiate the tumor from other small round cell malignancies postoperatively.
Observations: A 7-year-old patient was admitted to the authors' hospital due to the in situ recurrence of a posterior fossa tumor more than 1 month after the initial surgery for headache.
Obstruction from Deflux leading to significant kidney function loss and chemotherapeutic challenges in pediatric Ewing sarcoma.
Urol Case Rep
January 2025
Medical College of Georgia, Augusta, GA, USA.
This report presents the case of an 8-year-old female with a history of vesicoureteral reflux (VUR) treated with Deflux injections, who developed Ewing sarcoma metastasized to the lungs. Despite the initial resolution of VUR following Deflux procedures, recurrent urinary tract infections prompted further evaluation revealing significant ureteral obstruction. Pre-chemotherapy workup included renal ultrasonography, nuclear medicine renal scan, and cystogram, identifying obstructive uropathy necessitating bilateral ureteral stent placement.
View Article and Find Full Text PDFMulti-omics profiling reveals key factors involved in Ewing sarcoma metastasis.
Mol Oncol
January 2025
Sarcoma Research Group, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Oncobell, L'Hospitalet de Llobregat, Barcelona, Spain.
Ewing sarcoma (EWS) is the second most common bone tumor affecting children and young adults, with dismal outcomes for patients with metastasis at diagnosis. Mechanisms leading to metastasis remain poorly understood. To deepen our knowledge on EWS progression, we have profiled tumors and metastases from a spontaneous metastasis mouse model using a multi-omics approach.
View Article and Find Full Text PDFChallenges in Diagnosing Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor: A Case Report.
Curr Med Imaging
January 2025
Department of Radiology, Affiliated Hospital of Southwest Medical University, Sichuan, China.
Background: Primary intracranial Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor (EWS/pPNET) is exceedingly rare and easy to misdiagnose.
Case Presentation: We present a case involving a 23-year-old male who presented with headaches and vomiting. The preoperative brain imaging revealed an irregular mass in the left parietal lobe, initially misdiagnosed as meningioma.
Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines.
Nat Commun
January 2025
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity with strong phenotypical implications. Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!