AI Article Synopsis
- Migraine is a common neurological disorder often accompanied by vertigo and motion sickness, with genetic factors contributing to its development. A study examined a large American family where many members experienced these conditions.
- Using genome-wide linkage analysis, researchers analyzed the genetic markers of 29 family members, separating the conditions of migraine, vertigo, and motion sickness for their assessments.
- The study identified a new genetic locus for migraine and suggested separate genetic regions for vertigo and motion sickness, supporting the idea that these may have different underlying genetic causes.
Article Abstract
Background: Migraine is a common disorder most typically presenting as headache and often associated with vertigo and motion sickness. It is a genetically complex condition with multiple genes ultimately contributing to the predisposition and development of this episodic neurological disorder. We identified a large American family of 29 individuals of which 17 members suffered from at least one of these disorders, migraine, vertigo, or motion sickness. Many of these individuals suffered from several simultaneously. We hypothesized that vertigo and motion sickness may involve genes that are independent to those directly contributing to migraine susceptibility.
Methods: Genome-wide linkage analysis performed using 400 microsatellite repeat markers spaced at 10 cM throughout the genome. The members of this family were phenotyped for each condition, migraine, vertigo, and motion sickness and analyzed separately. Statistical analysis was performed using two-point and multipoint linkage analysis employing a number of models including autosomal recessive or dominant patterns of inheritance with high and low genetic penetrance.
Results: We identified a novel locus for migraine, 9q13-q22 (maximum two-point logarithm of odds [LOD] score-2.51). In addition, there are suggestive LOD scores that localize to different chromosomes for each phenotype; vertigo (chromosome 18, LOD score of 1.82) and motion sickness (chromosome 4, LOD score of 2.09).
Conclusions: Our analysis supports our hypothesis that the migraine-associated vertigo and motion sickness may involve distinct susceptibility genes.
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| http://dx.doi.org/10.1017/cjn.2019.64 | DOI Listing |
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