AI Article Synopsis
- - Telomeres, protective structures at the ends of chromosomes, shorten with each cell division and can be affected by lifestyle choices, especially due to obesity-induced inflammation.
- - The review explores how obesity leads to telomere shortening and identifies key risk factors influencing this process.
- - It concludes that telomere length may serve as a biomarker to measure the effectiveness of weight loss strategies on addressing obesity.
Article Abstract
Telomeres are structures located at the ends of chromosomes associated with proteins, from the shelterin complex, which are responsible for the protection and preservation of the genetic material. The telomere length (TL) progressively decreases with each cell division, and recent evidence suggests that lifestyle can lead to telomere shortening. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. Thus, the aim of the present review was to show the relationship between obesity and TL in addition to the possible risk factors for its shortening and how the different strategies for weight loss can modulate TL. As the crucial result, we can consider the association between TL and weight loss, and adiposity changes after different interventions, showing that TL may be used as a biomarker of responses to obesity treatment.
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| http://dx.doi.org/10.1016/j.nut.2019.05.002 | DOI Listing |
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