Background: Contact with child protective services (CPS) functions as an independent marker of child vulnerability. Alaska children are an important population for understanding patterns of CPS contact given high rates of contact overall and among specific demographic groups.
Objective: We aimed to identify longitudinal trajectory classes of CPS contact among Alaska Native/American Indian (AN/AI) and non-Native children and examine preconception and prenatal risk factors associated with identified classes.
Participants And Setting: We used data from the Alaska Longitudinal Child Abuse and Neglect Linkage (ALCANLink) project, a linkage of 2009-2011 Alaska Pregnancy Risk Assessment Monitoring System (PRAMS) births with administrative data including CPS records.
Methods: We conducted growth mixture modeling to identify trajectory classes of CPS contact from birth to age five years. We used Vermunt's three-step approach to examine associations with preconception and prenatal risk factors.
Results: Among AN/AI children, we identified three classes: 1) no/low CPS contact (75.4%); 2) continuous CPS contact (19.6%), and 3) early, decreasing CPS contact (5.0%). Among non-Native children, we identified four classes: 1) no CPS contact (81.3%); 2) low, increasing CPS contact (9.5%); 3) early, rapid decline CPS contact (5.8%); and 4) high, decreasing CPS contact (3.3%). Maternal substance use had the largest impact on probabilities of class membership, increasing the probability of membership in classes characterized by CPS contact, among both AN/AI and non-Native children.
Conclusions: Results reveal heterogeneity in longitudinal patterns CPS contact across early childhood among Alaska children and identify maternal substance use as an important target for primary prevention.
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http://dx.doi.org/10.1016/j.chiabu.2019.104044 | DOI Listing |
Gels
December 2024
Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Hydrogels are widely used in the field of adhesive materials. However, hydrogel adhesion has previously required the covalent graft of supramolecular groups on polymeric chains. In contrast to that, here, a hydrogel adhesion induced by covalent polymer entanglement between two hydrogel networks was reported.
View Article and Find Full Text PDFJ Phys Chem B
December 2024
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
The high activity of water in aqueous battery electrolytes can trigger side reactions, limiting their large-scale application. Additives that form contact pairs (CPs) with cations by coordinating with them can effectively reduce water's activity. However, due to the complex interactions between ions, additives, and solvent molecules and the fact that current strategies for additive screening primarily rely on static physical parameters, the dynamic mechanisms that govern the modulation of ion solvation sheaths are still poorly understood.
View Article and Find Full Text PDFJ Pharm Sci
December 2024
Drug Product Development, Medicine Development & Supply, GSK R&D, Collegeville, PA 19426, USA. Electronic address:
This study determined process conditions under which polystyrene (CPS) and zirconia (YSZ) beads cause similar breakage kinetics and temperature rise during manufacturing of drug nanosuspensions via wet bead milling and explored relative advantages of CPS beads, particularly for stress-sensitive compounds. Besides temperature and particle size measurements, a microhydrodynamic-based kinetic model simulated the conditions for CPS to achieve breakage rates equivalent to those of YSZ. A power law correlation was applied to find conditions conducive to temperature equivalency.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
In organic field-effect transistors (OFETs), the high carrier mobility of conjugated polymers (CPs) is significantly influenced by the maintenance of excellent coplanarity and aggregation, especially at the interface between the organic semiconductor and dielectric layer. Unfortunately, CPs typically exhibit poor coplanarity due to the single bond rotations between donor and acceptor units. Furthermore, there is relatively little research on the coplanarity of CPs at the interface.
View Article and Find Full Text PDFAnn Biomed Eng
December 2024
Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, 20133, Milan, Italy.
Drug-coated balloons (DCBs) aim to deliver drug-loaded surface coating upon inflation at specific vascular sites, yet the role of inflation pressure remains to be defined. We implement a new approach combining ex vivo stamping experiments with in silico simulations to study acute coating transfer by commercial DCBs. This methodology comprises 3 essential pillars: (I) DCB resin inflation and slicing into cylindrical segments for subsequent stamping onto porcine-excised tissue, (II) Numerical inflation of a full DCB replica in an idealized porcine vessel to predict in vivo interfacial contact pressures (CPs) and subsequent interfacial-level numerical stamping to calculate appropriate benchtop forces that recreate these in vivo CP values, and (III) ex vivo stamping experiments and optical analysis of the stamped surfaces (DCB segment and arterial tissue), using a standard high-resolution camera to visualize coating.
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