A BODIPY-based ratiometric probe for sensing and imaging hydrogen polysulfides in living cells.

Hydrogen polysulfides (HS, n > 1) have attracted increasing attention in biological systems due to its redox signaling effect. To illustrate the process of the physiological and pathological roles played by HS, accurate detection is highly desired. In this work, we report a BODIPY-based fluorescent probe (BDP-PHS) for ratiometric HS sensing. BDP-PHS shows higher sensitivity and selectivity ratiometric response toward HS than various biological related species. Moreover, BDP-PHS has been successfully applied in imaging of HS in living cells.