Pelleted feeds (PF) are popular in horse nutrition because of high palatability and improved feeding hygiene, but ingestion is faster for PF than for cereals or muesli feed. The aim of the study was to evaluate whether variable amounts of two PFs produced with different physical properties from the same batch of feed can affect feed intake patterns in horses. Chewing patterns were measured in six warmblood mares (519 ± 36.3 kg) on two PFs (small-sized PF1: ø 5 mm, length 21.9 ± 4.97 mm, large-sized PF2: edge length 15.6 ± 0.14 × 15.6 ± 0.08 mm, length 54.4 ± 9.59 mm) in three different amounts (1.0, 1.5, 2.0 kg) once per day additional to hay. PF 2 was ingested faster than PF1 for the meal size 1.0 kg, but PF 1 was ingested more rapidly with a reduced chewing intensity if the offered meal size increased. The ingestion of PF 2 tendentially elevated the chewing intensity at higher meal sizes. An additional, but inverted meal size effect compared to 1.0 kg, was observed for 1.5 kg, where PF 1 was ingested at a higher speed combined with a lower chewing intensity compared to PF 2. Independent from the offered amount, PF 2 induced a markedly increased saliva production combined with a higher daily water intake. Larger-sized pellets seem to intensify the chewing process and decelerate the ingestion time if the meal size becomes larger.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.rvsc.2019.06.014 | DOI Listing |
Endocrinology
January 2025
Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden.
Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor (GHSR), promotes food intake, other feeding behaviours and stimulates growth hormone (GH) release from the pituitary. Growth hormone secretagogues (GHS), such as GHRP-6 and MK-0677, are synthetic GHSR ligands that activate orexigenic Neuropeptide Y neurons that co-express Agouti-Related Peptide (AgRP) in the arcuate nucleus of the hypothalamus when administered systemically. Systemic GHRP-6 also stimulates GH release in humans and rats.
View Article and Find Full Text PDFAAPS J
January 2025
Clinical Pharmacology Modeling and Simulation, Amgen, One Amgen Center Drive, Thousand Oaks, CA, 91320-0777, USA.
Sotorasib is a novel KRAS inhibitor that has shown robust efficacy, safety, and tolerability in patients with KRAS mutation. The objectives of the population pharmacokinetic (PK) analysis were to characterize sotorasib population PK in healthy subjects and patients with advanced solid tumors with KRAS mutation from 6 clinical studies, evaluate the effects of intrinsic and extrinsic factors on PK parameters, and perform simulations to further assess the impact of identified covariates on sotorasib exposures. A two-compartment disposition model with three transit compartments for absorption and time-dependent clearance and bioavailability well described sotorasib PK.
View Article and Find Full Text PDFAm J Clin Nutr
January 2025
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:
Background: The precision of recorded eating times directly affects the estimation of eating architecture i.e. size, timing, and frequency of eating.
View Article and Find Full Text PDFTransl Anim Sci
January 2025
Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada.
A study was conducted to assess growth performance, methane (CH) emissions, and feeding behavior of feedlot steers consuming backgrounding and finishing diets with an essential oil blend (EO), monensin (Mon), and their combination (EO + Mon). The study was structured as a 2 × 2 factorial, with two feed additive treatments (Control, EO) and two monensin treatments (no Monensin, Monensin). One hundred Angus × steers were evenly distributed across each treatment into four pens, and each dietary phase consisted of four, 28-d periods.
View Article and Find Full Text PDFJ Nutr
January 2025
Clermont Auvergne University, EA 3533, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), CRNH Auvergne, Clermont-Ferrand, France; International Research Chair Health in Motion, Clermont Auvergne University Foundation, Clermont-Ferrand, France.
Physical activity has been shown to improve various aspects of metabolic health and is frequently applied as an intervention in the management and prevention of overweight/obesity. Chrono-exercise can be studied in relation to time of day and timing in relation to a meal, which encompasses chronology and duration of the temporal interval, but the latter has received limited attention to date. This brief review and meta-analysis investigates whether the timing of a meal subsequent to acute exercise, in children and adolescents with and without overweight/obesity, moderates eating behaviour and appetite.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!