Protein Rou is a human IgA2 myeloma protein that carries the isoallotype marker n A2m(2). Partial amino acid sequence of its H chain (alpha) shows that the hinge region and the CH2 domain are homologous to alpha 2-chain and the CH1 and the CH3 domains homologous to alpha 1. Moreover, the CH1 domain contains the H-L disulfide bond identical to alpha 1. It is concluded that Rou H chain is a hybrid molecule caused by a recombination between alpha 1 and alpha 2 genes. The recombination event occurred between alpha 1-exon 1 and alpha 2-exon hinge and corresponds to position 222-223 of the alpha-chain.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Relationship Between Maternal Serum Amyloid A Levels and Neonatal Outcomes in Preterm Births.
Cureus
December 2024
Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, ROU.
This study investigated the relationship between maternal serum amyloid A (SAA) levels, a biomarker of systemic inflammation, and specific neonatal outcomes in preterm birth (PTB). The study included 66 consecutive pregnant women hospitalized for spontaneous preterm delivery (ranging from 28 to 36 gestational weeks), at the Timisoara Municipal Hospital. The study measured mSAA levels to assess their potential as predictors of fetal outcomes (respiratory distress syndrome [RDS]), as well as their association with APGAR score, neonatal leukocyte count, and C-reactive protein (CRP) levels as indicators of neonatal status and response.
View Article and Find Full Text PDFA Three-Year Analysis of Mortality in Clostridioides difficile Patients in a Tertiary Center.
Cureus
November 2024
Infectious Diseases, Clinic Hospital of Tropical and Infection Diseases "Dr. Victor Babes", Bucharest, ROU.
Background/objectives: , an anaerobic bacillus ubiquitous in nature, is the leading cause of hospital-acquired diarrhoea and one of the main causes of mortality by nosocomial infections. We aimed to identify the main predictors of the risk of dying and the characteristics of a three-year cohort of patients hospitalised in our clinic that eventually had an unfavourable outcome.
Methods: We collected retrospectively available data for all patients hospitalised between January 1, 2021, and December 31, 2023.
Effects of Non-invasive Vagus Nerve Stimulation on Inflammatory Markers in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Cureus
October 2024
Neurology, Medical Research Group of Egypt (MRGE), Arlington, USA.
The international healthcare community has encountered several difficulties because of the COVID-19 pandemic brought on by SARS-CoV-2. COVID-19 can lead to an abnormal immune response that features excessive inflammation, so targeting the vagus nerve through non-invasive vagus nerve stimulation (nVNS) may hold promise as an intervention. This meta-analysis aimed to examine the outcomes of using nVNS on different inflammatory biomarkers in COVID-19 patients.
View Article and Find Full Text PDFUtility of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry in Periprosthetic Joint Infection Diagnosis.
Cureus
October 2024
Orthopedics and Traumatology, Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, ROU.
One of the most feared complications of arthroplasty surgery is septic loosening. Periprosthetic joint infection (PJI) requires an accurate and fast diagnosis, and identification of pathogen microorganisms is essential for successful treatment. While standard bacteriological cultures can identify bacteria in seven to 14 days with sensitivity ranging from 35% to 70% that could further be increased by sonication of the explanted prosthesis, we would like to review a more novel and faster method of PJI detection and bacterial identification.
View Article and Find Full Text PDFExtracellular Vesicle-Based Characterization of Stem Cell Phenotype in Glioblastomas.
Cureus
September 2024
Neurosurgery, Emergency Clinical County Hospital Of Targu Mures, Targu Mures, ROU.
Glioblastoma (GB) is the most common brain malignancy occurring in adult patients having an extremely low overall survival. Therefore, it is paramount to establish reliable and accurate diagnostic and prognostic markers to guide a personalized and more effective treatment. Molecular characterization of the tumor is the ultimate goal in GB management and comprises, among others, the study of the extracellular vesicles (EVs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!