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LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia.
Front Pharmacol
January 2025
Department of Anaesthesiology and Intensive Care Medicine, Faculty of General Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Târgu Mureș, Romania.
Knowledge of drug pharmacokinetics and tissue distribution is precious for ensuring patient safety and optimizing treatments. The varied use of local anesthetics, as well as the fact that anesthetics can sometimes have low therapeutic indices and numerous adverse drug reactions, makes any novel pharmacokinetics information valuable. The present manuscript describes a pharmacokinetic study of ropivacaine carried out after plane block anesthesia on an animal model, using high sensitivity, accurate, and precise LC-MS/MS bioanalysis.
View Article and Find Full Text PDFSelf-signaling colorimetric sensor for selective detection of dopamine based on CoFeO nanozyme accelerated dopamine polymerization.
Anal Chim Acta
February 2025
Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education, Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, 730070, Lanzhou, Gansu, China. Electronic address:
Background: Reliable and selective detection of dopamine is crucial for the early diagnosis of various diseases. Transition metal based-nanozymes have shown great promise in the field of colorimetric detection of dopamine due to their remarkable stability and exceptional catalytic efficiency. However, these transition metal-based nanozymes typically function through a chromogenic reaction that relies on additional organic substrates, such as 3,3',5,5'-tetramethylbenzidine, to generate a detectable signal.
View Article and Find Full Text PDFEntropy driven-based catalytic biosensors for bioanalysis: From construction to application-A review.
Anal Chim Acta
February 2025
Department of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University, 30 Gaotanyan, Shapingba, Chongqing 400038, China. Electronic address:
The rapid advancement of precision medicine and the continuous emergence of novel pathogens have presented new challenges for biosensors, necessitating higher requirements. Target amplification technology serves as the core component in biosensor construction. Enzyme-based amplification methods are often sensitive and selective but involve relatively complex operational steps, whereas enzyme-free amplification methods offer simplicity but frequently fail to meet both sensitivity and selectivity simultaneously.
View Article and Find Full Text PDFA Highly Sensitive Triple Quad LC-MS/MS Method Development and Validation for the Determination of Bexicaserin (LP352) in Human Plasma and Urine Matrices.
Biomed Chromatogr
February 2025
Department of Clinical Pharmacology and Pharmacometrics, Longboard Pharmaceuticals, Inc. is a part of Lundbeck as a wholly owned subsidiary of Lundbeck LLC, La Jolla, California, USA.
Bexicaserin is a highly selective agonist at the 5-HT receptor in clinical development for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). We report an LC-MS/MS method for the quantitative estimation of bexicaserin in human plasma and urine. The sample preparation involves the extraction of bexicaserin and internal standard (CD-bexicaserin; IS) from 150 μL plasma and 50 μL urine using a solid phase extraction method.
View Article and Find Full Text PDFQuality Control and Validation Issues in LC-MS-Based Metabolomics.
Methods Mol Biol
January 2025
Division of Systems Medicine, Department of Metabolism Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.
Metabolic profiling performed using untargeted metabolomics of different, complex biological samples aims to apply agnostic/holistic, hypothesis-free, analysis of the small molecules that are present in the analyzed sample. This approach has been the center of major investments and dedicated efforts from the research community for many years. However, limitations and challenges remain, particularly with regard to the validation and the quality of the obtained results.
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