-Isopentenyladenosine (iA) was isolated from a marine sponge sp. as the major cytotoxic constituent along with -isopentenyladenosine 5'-monophosphate (iAP) which was inactive. The structures of iA and iAP were assigned by a combination of the analysis of NMR spectroscopy and mass spectrometry. This is the first isolation of iA and iAP from a marine sponge.
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