[Comparative neurophysiological study of the nootropic drugs piracetam and centrophenoxine].

Effects of nootropic drugs on transcallosal evoked potential (TEP) and EEG spectra of the animal brain cortex and hippocamp were studied. It was found that piracetam and centrophenoxine exert similar effects on the amplitude of the primary TEP components, produce its increase and also a rise and stabilization of the predominant peak in distribution of EEG power spectrum that corresponds to the improvement of theta rhythm organization. The drugs exert different effects on the secondary positive TEP component; centrophenoxine induces a change in non-basic rhythm of EEG in rats. Based on the results obtained, the authors consider possible neurophysiological mechanisms of the nootropic effect and make a comparative analysis of the actions of the drugs.