Three previously undescribed cardenolides, acovenosigenin A 3---L-acofriopyranoside (1: ), 14-anhydroacovenosigenin A 3--[-D-glucopyranosyl-(1″→4')---L-acofriopyranoside] (2: ), and 14-anhydroacovenosigenin A 3--[-D-glucopyranosyl-(1″→4')---L-acovenopyranoside] (3: ), together with the two already known ones, 14-anhydrodigitoxigenin 3---D-glucopyranoside (4: ) and acospectoside A (5: ), were isolated from the leaves of . The influence of cardenolides 1: - 3: and acovenoside A (found in the genus) on three cancer cell lines (HT29, HCT116, and AGS) was also investigated. The most promising results, in comparison with oxaliplatin, were obtained for compound 1: , which was found to be highly cytotoxic for all tested cell lines, HT29 (IC = 63.49 nM), HCT116 (IC = 67.35 nM), and AGS (IC = 80.92 nM). Unfortunately, 1: also showed similar toxicity towards normal lymphocytes (IC = 98.03 nM).
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