Background: Carbon dioxide (CO) insufflation has become more commonly used in EUS-guided interventions in recent years. However, there is a paucity of information regarding methods by which to monitor in vivo CO levels. This study aimed to assess the feasibility of a novel noninvasive method to monitor transcutaneous partial pressure of CO [INSIDE:1] levels during EUS-guided drainage of peripancreatic fluid collections (PFCs). The safety of CO insufflation in EUS-guided interventions was also investigated.

Patients And Methods: Patients who underwent EUS-guided PFC drainage between September 2015 and December 2016 at Shengjing Hospital of China Medical University were prospectively enrolled in this study. [INSIDE:2] was measured in all patients using a noninvasive sensor throughout the procedure.

Results: There were 25 patients eligible to be included in this study. The mean procedure time was 53.1 min. The mean [INSIDE:2] level was 40 ± 4 mmHg and 48 ± 5 mmHg before and after the procedure, respectively. The mean peak [INSIDE:2] during the procedure was significantly higher at 53 ± 6 mmHg (P < 0.0001). No complications associated with CO insufflation such as CO narcosis, gas embolism, or arrhythmias were encountered.

Conclusions: [INSIDE:2] monitoring can accurately reflect the level of [INSIDE:3] continuously and noninvasively. CO insufflation is safe for patients undergoing relatively complicated EUS-guided drainage of PFCs.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038731PMC
http://dx.doi.org/10.4103/eus.eus_32_19DOI Listing

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