Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(--cymene)Ru(CHO)()](CFSO) () by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru(--cymene)(CHO)Cl] () and bis-pyridyl amide linker () in the presence of AgOSCF. This cationic ruthenium metalla-rectangle () has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (H-NMR), carbon nuclear magnetic resonance spectroscopy (C-NMR), H-H correlation spectroscopy (COSY), H-H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Significantly, the 2D cationic ruthenium metalla-rectangle showed better anticancer activity towards three different cell lines (A549, Caki-1 and Lovo) as compared with the parent ruthenium complex () and the commercially used drug, cisplatin.
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Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(--cymene)Ru(CHO)()](CFSO) () by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru(--cymene)(CHO)Cl] () and bis-pyridyl amide linker () in the presence of AgOSCF. This cationic ruthenium metalla-rectangle () has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (H-NMR), carbon nuclear magnetic resonance spectroscopy (C-NMR), H-H correlation spectroscopy (COSY), H-H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS).
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