Two new dimeric 1,4-benzoquinone derivatives, peniquinone A () and peniquinone B (), a new dibenzofuran penizofuran A (), and a new pyrazinoquinazoline derivative quinadoline D (4), together with 13 known compounds (-), were isolated from a marine-derived fungus sp. L129. Their structures, including absolute configurations, were elucidated by extensive spectroscopic data and electronic circular dichroism calculations. Compound exhibited cytotoxicity against the MCF-7, U87 and PC3 cell lines with IC values of 12.39 µM, 9.01 µM and 14.59 µM, respectively, while compound displayed relatively weak cytotoxicity activities against MCF-7, U87 and PC3 cell lines with IC values of 25.32 µM, 13.45 µM and 19.93 µM, respectively. Furthermore, compound showed weak quorum sensing inhibitory activity against CV026 with an MIC value of 20 μg/well.
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| http://dx.doi.org/10.3390/md17070383 | DOI Listing |
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