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Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease. | LitMetric
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Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease.

Maria Petrovna Kruglova Sergej Vital'evich Grachev Polina Olegovna Bulgakova Alexander Vladimirovich Ivanov Edward Danielevich Virus Ksenya Alexandrovna Nikiforova Anatolij Nikolaevich Fedoseev Galina Dmitrievna Savina Aslan Amirkhanovich Kubatiev

Lab Med

Department of Molecular and Cell Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia.

Published: January 2020

Objective: To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).

Methods: Case-control study including 50 patients with CKD and 20 healthy volunteers.

Results: SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).

Conclusion: CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.

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 Source
http://dx.doi.org/10.1093/labmed/lmz035DOI Listing

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