AI Article Synopsis
- A marine sponge was analyzed chemically, leading to the discovery of two new bioconjugates made of a meroterpene and a unique psammaplysin alkaloid.
- The structures of these compounds, named frondoplysins A and B, were determined using high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), and single-crystal X-ray diffraction techniques.
- Frondoplysin A demonstrated strong inhibitory activity against protein-tyrosine phosphatase 1B (PTP1B) with an IC value of 0.39 μM, indicating its potential as a therapeutic agent.
Article Abstract
The chemical investigation of the marine sponge discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A () and B () were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC value of 0.39 μM.
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| http://dx.doi.org/10.1021/acs.orglett.9b01754 | DOI Listing |
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