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Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers. | LitMetric

AI Article Synopsis

  • Chronic liver injury leads to the buildup of myofibroblasts, causing increased collagen and liver fibrosis, with no specific treatments currently available.
  • The study investigated whether mesenchymal stromal cells (MSCs) can reverse liver fibrosis and cirrhosis after a partial liver removal in mice that were induced to develop fibrosis.
  • Results showed that local treatment with high-dose MSCs significantly reduced collagen deposition in the treated liver lobes, while non-MSC-treated lobes showed no changes, indicating that MSCs may be more effective than fibroblasts in reducing fibrosis.

Article Abstract

Chronic liver injury leads to the accumulation of myofibroblasts resulting in increased collagen deposition and hepatic fibrogenesis. Treatments specifically targeting fibrogenesis are not yet available. Mesenchymal stromal cells (MSCs) are fibroblast-like stromal (stem) cells, which stimulate tissue regeneration and modulate immune responses. In the present study we assessed whether liver fibrosis and cirrhosis can be reversed by treatment with MSCs or fibroblasts concomitant to partial hepatectomy (pHx)-induced liver regeneration. After carbon tetrachloride-induced fibrosis and cirrhosis, mice underwent a pHx and received either systemically or locally MSCs in one of the two remaining fibrotic/cirrhotic liver lobes. Eight days after treatment, liver fibrogenesis was evaluated by Sirius-red staining for collagen deposition. A significant reduction of collagen content in the locally treated lobes of the regenerated fibrotic and cirrhotic livers was observed in mice that received high dose MSCs. In the non-MSC-treated counterpart liver lobes no changes in collagen deposition were observed. Local fibroblast administration or intravenous administration of MSCs did not ameliorate fibrosis. To conclude, local administration of MSCs after pHx, in contrast to fibroblasts, results in a dose-dependent on-site reduction of collagen deposition in mouse models for liver fibrosis and cirrhosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714167PMC
http://dx.doi.org/10.1111/jcmm.14508DOI Listing

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