Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building, Memphis, TN 38152, USA.
Published: April 2019
AI Article Synopsis
Article Abstract
A large body of and evidence indicates that Manuka honey resolves inflammation and promotes healing when applied topically to a wound. In this study, the effect of two different concentrations (0.5% and 3% v/v) of Manuka honey on the release of cytokines, chemokines, and matrix-degrading enzymes from neutrophils was examined using a differentiated HL-60 cell line model in the presence of inflammatory stimuli. The results indicate that 0.5% honey decreased TNF-α, IL-1β, MIP-1α, MIP-1β, IL-12 p70, MMP-9, MMP-1, FGF-13, IL-1ra, and IL-4 release, but increased MIP-3α, Proteinase 3, VEGF, and IL-8 levels. In contrast, 3% honey reduced the release of all analytes except TNF-α, whose release was increased. Together, these results demonstrate a dose-dependent ability of Manuka honey to modify the release of cytokines, chemokines, and matrix-degrading enzymes that promote or inhibit inflammation and/or healing within a wound. The findings of this study provide further guidance for the future use of Manuka honey in wounds or tissue engineering templates. Future investigation is warranted to validate the results and translate these results to physiologically relevant environments.
School of Environmental and Life Sciences, College of Engineering, Science and Environment, The University of Newcastle, Ourimbah, New South Wales, Australia.
There is increasing interest in research and application of natural bioactive compounds due to the growing demand for functional ingredients from the pharmaceutical, cosmetic and food industries. A major challenge is finding suitable natural plant resources for the development of functional ingredients. Leptospermum, a genus of the myrtle family (Myrtaceae), is primarily native to Australia.
Otorhinolaryngology and Head & Neck Surgery, Jain ENT Hospital, Jaipur, Rajasthan India 23-24, Satya Vihar Colony, Pankaj Singhavi Marg, Nr. Vidhan Sabha,Lal Kothi, 302015.
The aim of present study was to observe the effect of topical application of manuka honey in healing in the healing of postoperative mastoid cavity. A total of 100 patients diagnosed with chronic suppurative otitis media with cholesteatoma underwent canal wall down mastoidectomy, Manuka honey-soaked roller gauze pack was placed on Day 10 and was removed on day 17 and manuka honey was applied on day 17. Cavity was assessed on day 47 and day 90 on follow-up.
Trauma is a significant factor in skin surgical issues for cats, leading to higher infection risks, and the study investigates how platelet-rich fibrin (PRF) can aid in wound healing.
Researchers created trauma models in 18 cats, dividing them into three groups: a control group, a PRF group, and a Manuka honey group for positive comparison.
Results indicated that PRF effectively enhances wound healing without affecting the cat's vital signs, promoting growth factor production, reducing inflammation, and increasing collagen fiber formation, similar to the effects of Manuka honey.
Biofilms are major virulence factors formed by pathogenic bacteria to invade their host and maintain their colony. While biofilms usually develop on diverse solid surfaces, floating biofilms, also called pellicles, are formed at the air-liquid interface. To address the problem of biofilm formation by bacterial pathogens, honey has been extensively studied.
The study aimed to compare the antibacterial effects of four types of honey—two medical-grade and two non-medical-grade—against bacteria found in wounds of dogs and cats.
Results showed that medical-grade honey was the most effective in killing bacteria like Staphylococcus and Pseudomonas, while non-medical-grade honey had similar effects against some bacteria.
The findings suggest that medical-grade honey is best for treating wounds in pets, but more research is needed to fully understand the effectiveness of other honey types for veterinary use.
