We report the clinical and perimetric findings of three patients with ethambutol toxicity with an extended use regimen. In this observational case series, we extracted data from case records that included age, sex, complaints, details of the current disease, anti-tubercular therapy, ocular findings, and perimetric findings. We identified three patients, two female and one male with ages ranging from 16 to 65 years (mean: 37 years). The perimetric patterns we observed were incomplete homonymous hemianopia in two patients and bitemporal hemianopia in one. Incomplete hemianopia was the predominant perimetric finding, suggesting that the likely lesions were chiasmal or post-chiasmal rather than pre-chiasmal.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559692 | PMC |
http://dx.doi.org/10.7759/cureus.4408 | DOI Listing |
J Med Chem
January 2025
Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Glucagon-like peptide-1 receptor (GLP-1R) is a well-established target for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The development of orally bioavailable and long-acting small-molecule GLP-1R agonists is a pursuit in both academia and industry. Herein, new selenium (Se)-containing compounds were designed using a Se-oxygen bioisostere strategy on the danuglipron scaffold.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
School of Textile Science and Engineering, Jiangnan University, Wuxi 214021, China. Electronic address:
Perfluoroalkyl and poly-fluoroalkyl substances (PFAS) release from textiles is a source of human exposure, but the mechanisms behind this release remain insufficiently studied. This research investigates the release and transport mechanisms of PFAS in outdoor jacket fabrics treated with a short side-chain fluorinated polymers (CF-SFPs) for durable water repellency (DWR). PA-based and PET-based fabrics were exposed to outdoor conditions and subjected to accelerated aging, followed by abrasion, washing, and drying experiments to simulate wear and degradation.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
School of Pharmacy, Queen's University Belfast, Lisburn Road 97, Belfast, BT9 7BL, UK.
Implantable drug delivery systems are crucial for achieving sustained delivery of active compounds to specific sites or systemic circulation. In this study, a novel reservoir-type implant combining a biodegradable rate-controlling membrane with a drug-containing core prepared using direct compression techniques is developed. The membrane is composed of poly(caprolactone) (PCL), and risperidone (RIS) served as the model drug.
View Article and Find Full Text PDFEpilepsia
January 2025
Epilepsy Unit, Gui de Chauliac Hospital, Montpellier, France.
Nonconvulsive status epilepticus (NCSE) was initially described in patients with typical and atypical absence status epilepticus (ASE) characterized by states of confusion varying in severity and in focal epilepsies with or without alteration of consciousness. Continuous EEG monitoring of critically ill patients has further refined the classification of NCSE into two main categories: with coma and without coma. Hypnotic, soporific or somniferous epileptic seizures do not exist.
View Article and Find Full Text PDFLab Chip
January 2025
Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China.
Organ-on-a-chip culture systems using human organ tissues provide invaluable preclinical insights into systemic functions . This study aimed to develop a novel human testicular tissue chip within a microfluidic device employing computer-aided design software and photolithography technology. Polydimethylsiloxane was used as the primary material to ensure marked gas permeability and no biotoxicity, enabling effective mimicry of the testicular microenvironment.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!