Alzheimer's disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (Aβ) plaques. However, less than 5% of AD cases are familial, with many additional risk factors contributing to AD including aging, lifestyle, the environment and epigenetics. Recent epigenome-wide association studies (EWAS) of AD have identified a number of loci that are differentially methylated in the AD cortex. Indeed, hypermethylation and reduced expression of the () gene in AD has been reported in the cortex in numerous different post-mortem brain cohorts. Little is known about the normal function of ANK1 in the healthy brain, nor the role it may play in AD. We have generated models to allow us to functionally characterize , the ortholog of human and to determine its interaction with human Tau and Aβ. We show expression of human Tau 0N4R or the oligomerizing Aβ 42 amino acid peptide caused shortened lifespan, degeneration, disrupted movement, memory loss, and decreased excitability of memory neurons with co-expression tending to make the pathology worse. We find that with reduced neuronal expression have shortened lifespan, reduced locomotion, reduced memory and reduced neuronal excitability similar to flies overexpressing either human Tau 0N4R or Aβ42. Therefore, we show that the mis-expression of can drive disease relevant processes and phenocopy some features of AD. Therefore, we propose targeting human ANK1 may have therapeutic potential. This represents the first study to characterize an AD-relevant gene nominated from EWAS.
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http://dx.doi.org/10.3389/fncel.2019.00260 | DOI Listing |
J Invertebr Pathol
January 2025
Aquaculture Pathology Laboratory, School of Animal and Comparative Biomedical Science, University of Arizona, Tucson, AZ 85921, United States.
Captive, pelagic red crabs (Pleuroncodes planipes) had shortened lifespans and cutaneous black spots. Histologically, epidermal and mesenchymal cells had 3-5 µm diameter intranuclear inclusions, necrosis, vacuolation, and/or hyperplasia. The remaining organs were histologically unremarkable.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Department of Materials Science and Engineering, Shaanxi Province Key Laboratory of Corrosion and Protection, Xi'an University of Technology, Xi'an 710048 PR China.
Pitting corrosion caused by sulfate-reducing bacteria (SRB) significantly shortens the lifespan of metallic pipelines. Antibacterial coatings containing S-responsive drug-loaded nanocontainers represent a promising method to mitigate SRB corrosion. However, the challenge of balancing rapid bactericide release with continuous antibacterial effect limits their practical application.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
An important question in restoration ecology is whether restored ecological regimes are more vulnerable to transitions back to a degraded state. In woody-invaded grasslands, high-intensity fire can collapse woody plant communities and induce a shift back to a grass-dominated regime. Yet, legacies from woody-dominated regimes often persist and it remains unclear whether restored regimes are at heightened vulnerability to reinvasion.
View Article and Find Full Text PDFBull Entomol Res
January 2025
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Understanding the interactive effects of temperature and diet on insect life cycles is crucial for effective pest management. Here, the influence of different temperatures and diets on the life cycle of was investigated using the age-stage, two-sex life table analysis. The results support the hypothesis that temperature and diets (maize, apple, and artificial diet) significantly influence the entire life cycle performance of .
View Article and Find Full Text PDFJ Prim Care Community Health
January 2025
University of New South Wales, Sydney, NSW, Australia.
Introduction/objectives: Individually rare, rare diseases are collectively common resulting in frequent health system use. Navigating the health system persists as a challenge. Primary care provides longitudinal contact with the health system and is placed to provide integrated rare-disease-care.
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