Immunoregulation and differentiation markers in monoclonal gammopathies.

Multiple myeloma and benign monoclonal gammopathies (BMG) are regarded as monoclonal B cell proliferations in which B lymphocyte maturation is blocked in the final stages of the differentiation cycle. Further studies with monoclonal antibodies (MoAbs) of the FMC series and of the 791T/36 MoAb will perhaps provide a final subclassification of the B lymphocyte proliferation diseases and hopefully assist in their diagnosis and treatment.