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| http://dx.doi.org/10.46582/jsrm.1501004 | DOI Listing |
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The MiT/TFE family gene fusion proteins, such as , drive both epithelial (eg, translocation renal cell carcinoma, tRCC) and mesenchymal (eg, perivascular epithelioid cell tumor, PEComa) neoplasms with aggressive behavior. However, no prior mouse models for -related tumors exist and the mechanisms of lineage plasticity induced by this fusion remain unclear. Here, we demonstrate that constitutive murine renal expression of human using Ksp Cadherin-Cre as a driver disrupts kidney development leading to early neonatal renal failure and death.
View Article and Find Full Text PDFCell Population-resolved Multi-Omics Atlas of the Developing Lung.
Am J Respir Cell Mol Biol
October 2024
Pacific Northwest National Laboratory, Biological Science Division, Richland, Washington, United States;
The lung is a vital organ that undergoes extensive morphological and functional changes during postnatal development. To disambiguate how different cell populations contribute to organ development, we performed proteomic and transcriptomic analyses of four sorted cell populations from the lung of human subjects aged 0 to 8 years-old with a focus on early life. The cell populations analyzed included epithelial, endothelial, mesenchymal, and immune cells.
View Article and Find Full Text PDFCharacterization and angiogenic potential of CD146 endometrial stem cells.
Stem Cell Res Ther
September 2024
Department of Stem Cells & Regenerative Medicine, D.Y. Patil Education Society (Deemed to be University), D. Y. Patil Vidyanagar, Kasab Bawada, Kolhapur, 416006, Maharashtra, India.
Article Synopsis
- - The study investigates the role of endometrial stem cells (eSCs) in tissue regeneration and angiogenesis, particularly focusing on CD146 as a key marker that enhances the regenerative and vascular growth potential of these cells.
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Administration of adipose-derived stem cells extracellular vesicles in a murine model of spinal muscular atrophy: effects of a new potential therapeutic strategy.
Stem Cell Res Ther
April 2024
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Background: Spinal Muscular Atrophy (SMA) is an autosomal-recessive neuromuscular disease affecting children. It is caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene resulting in lower motor neuron (MN) degeneration followed by motor impairment, progressive skeletal muscle paralysis and respiratory failure. In addition to the already existing therapies, a possible combinatorial strategy could be represented by the use of adipose-derived mesenchymal stem cells (ASCs) that can be obtained easily and in large amounts from adipose tissue.
View Article and Find Full Text PDFAxin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells.
Int Endod J
August 2023
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Med-X Center for Materials, Sichuan University, Chengdu, China.
Aim: Inducing odontogenic differentiation and tubular dentine formation is extremely important in dentine repair and tooth regeneration. Bone morphogenic proteins (BMPs) signalling plays a critical role in dentine development and tertiary dentine formation, whilst how BMPR1A-mediated signalling affects odontoblastic differentiation of Axin2-expressing (Axin2 ) odontogenic cells and tubular dentine formation remains largely unknown. This study aims to reveal the cellular and molecular mechanisms involved in the formation of secondary dentine.
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