The tripeptide Tyr-Gly-Gly (YGG) was established as an endogenous constituent in rat brain. Its origin from enkephalin neurons is suggested by its regional distribution paralleling that of (Met5)-enkephalin (YGGFM), its decrease following kainate-induced ablation of the striato-pallidal neurons and its enhanced formation following depolarization of pallidal slices. Enkephalinase (EC 3.4.24.11) is selectively responsible for endogenous YGG formation in vitro and in vivo.
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Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids.
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Article Synopsis
- - The University at Buffalo's theoretical databank of aspherical pseudoatoms enhances the refinement of X-ray diffraction data from peptides, improving accuracy in bond lengths, angles, and phase angles.
- - Using this databank for low-resolution data significantly reduces the R factor and enhances the determination of atomic displacement parameters and bonding features, compared to conventional methods.
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