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Efficacy and Safety of Nemolizumab in Patients With Moderate to Severe Prurigo Nodularis: The OLYMPIA 1 Randomized Clinical Phase 3 Trial.
JAMA Dermatol
November 2024
Department of Dermatology, University of Maryland School of Medicine, Baltimore.
Importance: Prurigo nodularis (PN) is a chronic and debilitating skin condition, characterized by intense itch with multiple nodular lesions. Nemolizumab demonstrated significant improvements in itch and skin nodules in adults with moderate to severe PN in a previous 16-week phase 3 study (OLYMPIA 2).
Objective: To assess the efficacy and occurrence of adverse events in adults with moderate to severe PN treated with nemolizumab vs those receiving placebo.
Interobserver Agreement in Ultrasound Risk Stratification Systems for Thyroid Nodules on Static Images Versus Cine-Loop Video Sequences.
Diagnostics (Basel)
September 2024
Clinic of Nuclear Medicine, University Hospital Jena, 07747 Jena, Germany.
Article Synopsis
- The study aims to assess how video sequences (cine-loops) affect the agreement between different observers when using risk stratification systems (RSSs) to evaluate thyroid nodules (TNs).
- Twelve experienced observers assessed twenty randomly selected TNs first using static ultrasound images and then again six months later using video sequences, with interobserver agreement measured using Fleiss' kappa (κ).
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Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists.
Endocrine
January 2025
Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Article Synopsis
- An online survey of European thyroid specialists revealed that 28% believe thyroid hormone (TH) treatment may be appropriate for euthyroid patients with growing simple goiters, despite guidelines against this practice.
- There were significant regional differences in support for TH treatment, with only 7% in The Netherlands compared to 78% in the Czech Republic.
- Factors influencing the likelihood of recommending TH included the specialist's age and the historical iodine insufficiency of their region, while gender, country, and economic factors showed weak associations.
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial.
CNS Drugs
August 2024
Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, 75-59 263rd St, Glen Oaks, NY, 11004, USA.
Background: TV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United States Food and Drug Administration for the treatment of schizophrenia in adults. In the phase 3, randomized, double-blind RIsperidone Subcutaneous Extended-release (RISE) study, TV-46000 once monthly (q1m) and once every 2 months (q2m) significantly prolonged time to impending relapse compared with placebo [5.0-fold (q1m) and 2.
View Article and Find Full Text PDFIntraductal papillary neoplasms of the bile ducts-what can be seen with ultrasound?
Endosc Ultrasound
December 2023
Department of Internal Medicine (DAIM). Hirslanden Private Hospital Beau Site, Salem und Permanence, Bern, Switzerland.
Intraductal papillary neoplasm of the bile ducts is a rare tumor. Characteristic features include bile duct dilatation, cystic lesions with communication to the bile ducts, and intraluminal solid nodules arising from the bile duct wall. As in pancreatic intraductal papillary mucinous neoplasia, intestinal, pancreaticobiliary, gastric, and oncocytic types are described.
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