AI Article Synopsis
- Over 10 million people worldwide suffer from corneal blindness due to trauma or disease, often requiring corneal transplantation.
- Donor shortages and rejection risks complicate treatment, and while progress in understanding healing processes has been made, they remain complex.
- Tissue engineering and regenerative medicine are promising fields exploring new therapies to restore the cornea's structure and function, as highlighted in this comprehensive review.
Article Abstract
Currently, over 10 million people worldwide are affected by corneal blindness. Corneal trauma and disease can cause irreversible distortions to the normal structure and physiology of the cornea often leading to corneal transplantation. However, donors are in short supply and risk of rejection is an ever-present concern. Although significant progress has been made in recent years, the wound healing cascade remains complex and not fully understood. Tissue engineering and regenerative medicine are currently at the apex of investigation in the pursuit of novel corneal therapeutics. This review uniquely integrates the clinical and cellular aspects of both corneal trauma and disease and provides a comprehensive view of the most recent findings and potential therapeutics aimed at restoring corneal homeostasis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703935 | PMC |
| http://dx.doi.org/10.1016/j.exer.2019.107709 | DOI Listing |
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