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The decline in the clinical relevance of pilocarpine and physostigmine monitored in pharmacology textbooks from 1878 to 2023: nine take-home messages for future (pharmacology) textbook authors.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover, 30625, Germany.
In a recent study, using hydrogen cyanide as paradigm, we have shown that pharmacological knowledge evolves non-linearly ( https://pubmed.ncbi.nlm.
View Article and Find Full Text PDFBeyond lines of treatment: embracing early high-efficacy disease-modifying treatments for multiple sclerosis management.
Ther Adv Neurol Disord
October 2024
Clinical Neuroimmunology Unit and CSUR Multiple Sclerosis, Neurology Department, Hospital Clínico Universitario Virgen de la Arrixaca (IMIB-Arrixaca)/Cátedra de Neuroinmunología Clínica y Esclerosis Múltiple, Universidad Católica San Antonio, Murcia, Spain.
Recent advances in multiple sclerosis (MS) management have shifted perspectives on treatment strategies, advocating for the early initiation of high-efficacy disease-modifying therapies (heDMTs). This perspective review discusses the rationale, benefits, and challenges associated with early heDMT initiation, reflecting on the obsolescence of the traditional "first-line" and "second-line" treatment classifications. The article emerges from the last update of the consensus document of the Spanish Society of Neurology on the treatment of MS.
View Article and Find Full Text PDFBuilding and environmental acoustics in obsolete residential neighbourhoods: The case of San Pablo, Spain.
Heliyon
September 2023
Instituto Universitario de Arquitectura y Ciencias de la Construcción (IUACC), Departamento de Construcciones Arquitectónicas I, Escuela Técnica Superior de Arquitectura, Universidad de Sevilla, Avenida Reina Mercedes 2, 41012, Seville, Spain.
In order to establish an agreement between the objectives of acoustic quality in the outdoor environment and the acoustic insulation in a building as required in the current legislation in Spain, the acoustic insulation of typical social housing has been studied in the residential neighbourhood of San Pablo in Seville. Field measurements based on acoustic sonometry have been performed in its public areas, together with the consultations to the strategic noise maps prepared by the administration of the city and with data from a questionnaire answered by neighbours on the perception of environmental and domestic noise. These inputs have enabled calculations of airborne and impact noise insulation in a typical dwelling of the neighbourhood.
View Article and Find Full Text PDFThe Party Should Not Last That Long.
J Innov Card Rhythm Manag
January 2023
Department of Medicine, Division of Cardiology, Columbia University, New York, NY, USA.
Too much food, too much wine, and too many friends. You'll pay the price tomorrow; you shouldn't have let the party last so long. This analogy seems apt with respect to our new understanding of atrial fibrillation (AF) and approaches to AF.
View Article and Find Full Text PDFMedical Ethics as Taught and as Practiced: Principlism, Narrative Ethics, and the Case of Living Donor Liver Transplantation.
J Med Philos
February 2022
University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
The dominant model for bioethical inquiry taught in medical schools is that of principlism. The heritage of this methodology can be traced to the Enlightenment project of generating a universalizable justification for normative morality arising from within the individual, rational agent. This project has been criticized by Alasdair MacIntyre who suggests that its failure has resulted in a fragmented and incoherent contemporary ethical framework characterized by fundamental intractability in moral debate.
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