AI Article Synopsis
- The modern world is filled with numerous substances that can be toxic to the kidneys, making research into their effects complex due to their interactions and metabolism.
- Acute kidney injury (AKI) can result from exposure to nephrotoxic agents through various means, including ingestion, inhalation, or hospital-related exposure, and can stem from plants, animal toxins, medications, and drugs.
- The review details the different causes of nephrotoxic injuries, as well as the diagnosis, clinical signs, and management strategies for treating poisoning and related kidney dysfunction.
Article Abstract
Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nephrotoxic substances, may be community acquired with ingestion or inhalation or nosocomial. Many nephrotoxic plants, animal poisons, medications, chemicals and illicit drugs can induce AKI by varying pathophysiological pathways. Moreover, the epidemiology of toxic AKI varies depending on country, regions within countries, socioeconomic status and health care facilities. In this review, we have selected nephrotoxic insults due to medication, plants, animal including snake venom toxicity, environmental, (agri)chemicals and also illicit drugs. We conclude with a section on diagnosis, clinical presentation and management of poisoning accompanied by various organ dysfunction and AKI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598532 | PMC |
| http://dx.doi.org/10.1080/0886022X.2019.1628780 | DOI Listing |
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