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Polyphenol Mediated Assembly: Tailored Nano-Dredger Unblocks Axonal Autophagosomes Retrograde Transport Traffic Jam for Accelerated Alzheimer's Waste Clearance.
Adv Mater
December 2024
Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
Clear-cut evidence has linked defective autophagy to Alzheimer's disease (AD). Recent studies underscore a unique hurdle in AD neuronal autophagy: impaired retrograde axonal transport of autophagosomes, potent enough to induce autophagic stress and neurodegeneration. Nonetheless, pertinent therapy is unavailable.
View Article and Find Full Text PDFModeling traffic pollutants in a street canyon by CFD: Idealized line sources versus multiple realistic car sources.
Sci Total Environ
December 2024
Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland, United Kingdom; Building Physics and Sustainable Design, Department of Civil Engineering, KU Leuven, Leuven, Belgium. Electronic address:
Idealized sources are commonly used to reproduce the traffic emission in street canyons in experimental and numerical investigations. However, it remains unclear whether idealized sources can accurately reproduce the pollutant dispersion compared to more realistic sources. The goal of this paper is to investigate the impact of idealized and realistic sources on traffic-induced pollutant concentration in a street canyon by numerical simulation with Computational Fluid Dynamics (CFD).
View Article and Find Full Text PDFTransgenic Expressing Active Human LH Receptor in the Gonads Exhibit a Decreased Fecundity: Towards a Platform to Identify New Orally Active Modulators of Gonadotropin Receptor Activity.
Pharmaceuticals (Basel)
September 2024
Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba 8410501, Israel.
Background/objectives: The gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and their receptors are major regulators of reproduction in mammals and are absent in insects. We previously established transgenic lines expressing a constitutively active human LH receptor variant (LHR) and the wild-type receptor (LHR; inactive in the absence of an agonist). That study showed that ubiquitously expression of LHR-but not of LHR-resulted in pupal lethality, and targeted expression in midline cells resulted in thorax/bristles defects.
View Article and Find Full Text PDFRelieving the transfusion tissue traffic jam: a network model of radial transport in conifer needles.
New Phytol
December 2024
Department of Physics, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Characteristic of all conifer needles, the transfusion tissue mediates the radial transport of water and sugar between the endodermis and axial vasculature. Physical constraints imposed by the needle's linear geometry introduce two potential extravascular bottlenecks where the opposition of sugar and water flows may frustrate sugar export: one at the vascular access point and the other at the endodermis. We developed a network model of the transfusion tissue to explore how its structure and composition affect the delivery of sugars to the axial phloem.
View Article and Find Full Text PDFUnlabelled: Transposable elements (TEs) pose a threat to genome integrity, and the piRNA pathway in animal gonads plays a crucial role in silencing TE activity. While the transcriptional regulation of the piRNA pathway components in germ cells has been documented in mice and flies, the mechanisms orchestrating the transcriptional program of the somatic piRNA pathway in ovaries remains unresolved. Here, we demonstrate that Traffic jam (Tj), an orthologue of a large Maf transcription factor in mammals, is a master regulator of the piRNA pathway in ovarian somatic cells, playing a crucial role in maintaining TE silencing and genomic integrity in somatic tissues.
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