Unsupervised learning makes manifest the underlying structure of data without curated training and specific problem definitions. However, the inference of relationships between data points is frustrated by the "curse of dimensionality" in high dimensions. Inspired by replica theory from statistical mechanics, we consider replicas of the system to tune the dimensionality and take the limit as the number of replicas goes to zero. The result is intensive embedding, which not only is isometric (preserving local distances) but also allows global structure to be more transparently visualized. We develop the Intensive Principal Component Analysis (InPCA) and demonstrate clear improvements in visualizations of the Ising model of magnetic spins, a neural network, and the dark energy cold dark matter ([Formula: see text]) model as applied to the cosmic microwave background.
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http://dx.doi.org/10.1073/pnas.1817218116 | DOI Listing |
Pharmacotherapy
January 2025
Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, Georgia, USA.
Background: Fluid overload (FO) in the intensive care unit (ICU) is common, serious, and may be preventable. Intravenous medications (including administered volume) are a primary cause for FO but are challenging to evaluate as a FO predictor given the high frequency and time-dependency of their use and other factors affecting FO. We sought to employ unsupervised machine learning methods to uncover medication administration patterns correlating with FO.
View Article and Find Full Text PDFDrug Des Devel Ther
January 2025
Department of Cardiology, The Seventh Affiliated Hospital of Southern Medical University, Southern Medical University, Foshan, 528244, People's Republic of China.
Purpose: The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS). However, the therapeutic effects, primary bioactive ingredients, and potential mechanisms underlying hypercholesterolemia and AS remain unclear. This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.
View Article and Find Full Text PDFCureus
December 2024
Department of Emergency and Intensive Care Medicine, Hospital of the University of Occupational and Environmental Health, Fukuoka, JPN.
Objectives The objective of this study was to evaluate the occupational radiation exposure of healthcare workers during positron emission tomography (PET)/CT examinations, focusing on patient positioning and assessing the effectiveness of different radiation protection measures. Methods Thirteen medical workers (physicians, radiological technologists, and nurses) performed PET/CT examinations on 86 patients at a major Japanese hospital from June to August 2019. Occupational doses were measured using a real-time semiconductor dosimeter: RaySafe i2 (Unfors RaySafe, Billdal, Sweden), recording the 1 cm dose equivalent (Hp(10)).
View Article and Find Full Text PDFNat Med
January 2025
Department for Preventive Sports Medicine and Sports Cardiology, Technical University of Munich, School of Medicine and Health, TUM University Hospital, Munich, Germany.
Endurance exercise training (ET) is an effective treatment in heart failure with preserved ejection fraction (HFpEF), but the efficacy of resistance training in this patient population has been only scarcely evaluated. In this multicenter, randomized trial, we evaluated the effects of combined endurance and resistance training over 12 months in patients with HFpEF. The primary endpoint was a modified Packer score, including all-cause mortality, hospitalizations classified as potentially related to heart failure or exercise and changes in peak oxygen consumption ( ), diastolic function (E/e'), New York Heart Association (NYHA) class and global self-assessment (GSA).
View Article and Find Full Text PDFeNeuro
January 2025
Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Department of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Epilepsy, a neurological disorder characterized by recurrent unprovoked seizures, significantly impacts patient quality of life. Current classification methods focus primarily on clinical observations and electroencephalography (EEG) analysis, often overlooking the underlying dynamics driving seizures. This study uses surface EEG data to identify seizure transitions using a dynamical systems-based framework-the taxonomy of seizure dynamotypes-previously examined only in invasive data.
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