: This randomized controlled trial (RCT) evaluates the effectiveness of a self-management toolbox designed to maintain work ability and vitality in coach drivers over their peak season. : The intervention group received a self-management intervention providing advice aimed at increasing work ability and vitality. These suggestions targeted three specific domains: work-recovery-rest balance, food and drink intake, and physical activity. At the beginning (March), middle (July), and end (October) of the coach sector peak season, work ability, vitality, work-related fatigue, psychosomatic health, sleep complaints, and perceived mental exertion of coach drivers were assessed through questionnaires. : A total of 96 drivers participated in the study. Access to the toolbox did not result in significant differences between groups. Work ability and vitality decreased significantly in both groups, falling from 7.8 ± 1.3 to 7.3 ± 1.6 and from 63 ± 16.7 to 55 ± 18.7, respectively. Work-related fatigue increased from 35 ± 31.9 to 52 ± 35.3. Psychosomatic health complaints, sleep complaints, and perceived mental exertion also increased significantly. : The uptake of the intervention was too low to determine if this toolbox can maintain work ability and vitality in coach drivers when compared with a control group. Overall work ability and vitality decrease significantly as the peak season progresses, while work-related fatigue accumulates. Other interventions should be explored to ensure sustainable employability in this population.
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http://dx.doi.org/10.3390/ijerph16122214 | DOI Listing |
Med Chem
January 2025
Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences of Agadir, Ibn Zohr University, Agadir, Morocco.
Background: We continue to struggle with the prevention and treatment of the influenza virus. The 2009 swine flu pandemic, caused by the H1N1 strain of influenza A, resulted in numerous fatalities. The threat of influenza remains a significant concern for global health, and the development of novel drugs targeting these viruses is highly desirable.
View Article and Find Full Text PDFBiomacromolecules
January 2025
School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Polymer-based photosensitizers have found various applications in photodynamic therapy (PDT). However, the absence of targeting ability commonly results in a substantial reduction in photosensitizer accumulation at the tumor site, significantly limiting the therapeutic efficacy of the system. In addition, the development of biodegradable polymeric photosensitizers is of critical importance for biological applications.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Chemistry, University of North Bengal, Raja Rammohanpur, Siliguri 734013, West Bengal, India.
Self-assembly of amino acids and short-peptide derivatives attracted significant curiosity worldwide due to their unique self-assembly process and wide variety of applications. Amino acid is considered one of the important synthons in supramolecular chemistry. Self-assembly processes and applications of unfunctionalized native amino acids have been less reported in the literature.
View Article and Find Full Text PDFJ Clin Transl Endocrinol
March 2025
Department of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, PR China.
Objectives: This study aimed to evaluate the diagnostic performance for medullary thyroid cancer (MTC) based on the 2017 Thyroid Imaging Reporting and Data System by the American College of Radiology (ACR TI-RADS) guideline, and the ability to recommend fine needle aspiration (FNA) for MTC.
Methods: Fifty-six MTCs were included, and 168 benign thyroid nodules (BTNs) and 168 papillary thyroid nodules (PTCs) were matched according to age. Ultrasound (US) features were reviewed according to ACR TI-RADS.
Mater Today Bio
February 2025
Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China.
Sepsis is a serious and life-threatening condition, which can lead to organ failure and death clinically. Abnormally increased cell-free DNA (cfDNA) and inflammatory cytokines are involved in the development and progression of sepsis. Thus, cfDNA clearance and down-regulation of inflammatory factors are essential for the effective treatment of sepsis.
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