Visual working memory (VWM) represents the surrounding world in an active and accessible state, but its capacity is severely limited. To better understand VWM and its limits, we collected data from over 3,800 participants in the canonical change detection task. This unique population-level data-set sheds new light on classic debates regarding VWM capacity. First, the result supported a view of VWM as an active process, as manifested by the fact that capacity estimates were not stable across set-sizes, but rather lower for the larger set-size. Another support for this notion came from the tight connection capacity estimates had with a measure of attentional control. Together, the data suggested that individual differences in capacity do not reflect only differences in storage-size, but differences in the efficiency of using this storage. Second, we found a response bias such that subjects are more likely to respond that the probed item changed, and this criterion bias was further shifted as the set-size increased. These findings are naturally explained by a slot-like theory arguing that when load exceeds capacity, certain items remain completely outside of VWM (instead of all items being represented in lower resolution), therefore causing subjects to perceive them as different from VWM contents even when they are unchanged. Additionally, we found that the pattern of d' also confirmed the predictions of a slot-like view of VWM, such that some items are represented with high fixed resolution and others are not represented at all, although this finding is based on two measures with very different underlying assumptions. We also discuss how flexible-resource views can accommodate these results. Moreover, comparing performance between the first and last trials demonstrated no evidence for proactive interference as the driving factor of capacity limitations. We provide further details regarding the distribution of individual capacity, the relations between capacity and demographic variables, and the spatial prioritization of the items.
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http://dx.doi.org/10.1016/j.cognition.2019.05.021 | DOI Listing |
Am J Emerg Med
January 2025
Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; Emergency Department, Hospital Clínico Universitario, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain.
Background: The study of the inclusion of new variables in already existing early warning scores is a growing field. The aim of this work was to determine how capnometry measurements, in the form of end-tidal CO2 (ETCO2) and the perfusion index (PI), could improve the National Early Warning Score (NEWS2).
Methods: A secondary, prospective, multicenter, cohort study was undertaken in adult patients with unselected acute diseases who needed continuous monitoring in the emergency department (ED), involving two tertiary hospitals in Spain from October 1, 2022, to June 30, 2023.
J Nurs Adm
December 2024
Author Affiliation: Former Executive Vice President and Chief Nursing Officer, Advocate Health, Charlotte, North Carolina.
In 2024, Mary Beth Kingston, PhD, RN, FAAN, received the American Organization for Nursing Leadership (AONL) prestigious Lifetime Achievement Award. This award honors an AONL member recognized by the nursing community as a significant leader in the nursing profession and who has served AONL in an important leadership capacity. Kingston retires in December 2024 from her position as executive vice president and chief nursing officer at Advocate Health, Charlotte, North Carolina, the nation's 3rd largest nonprofit integrated health system.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Section on Perception, Cognition, Action, Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892.
To what extent does concept formation require language? Here, we exploit color to address this question and ask whether macaque monkeys have color concepts evident as categories. Macaques have similar cone photoreceptors and central visual circuits to humans, yet they lack language. Whether Old World monkeys such as macaques have consensus color categories is unresolved, but if they do, then language cannot be required.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Center for Environmental Economics - Montpellier (Univ Montpellier, CNRS, INRAE, Institut Agro), Montpellier 34000, France.
Collaborative management partnerships (CMPs) between state wildlife authorities and nonprofit conservation organizations to manage protected areas (PAs) have been used increasingly across Sub-Saharan Africa since the 2000s. They aim to attract funding, build capacity, and increase the environmental effectiveness of PAs. Our study documents the rise of CMPs, examines their current extent, and measures their effectiveness in protecting habitats.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Laboratory of Precision Medicine and Biopharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Recurrent missense mutations in the human epidermal growth factor receptor 2 (HER2) have been identified across various human cancers. Among these mutations, the active S310F mutation in the HER2 extracellular domain stands out as not only oncogenic but also confers resistance to pertuzumab, an antibody drug widely used in clinical cancer therapy, by impeding its binding. In this study, we have successfully employed computational-aided rational design to undertake directed evolution of pertuzumab, resulting in the creation of an evolved pertuzumab variant named Ptz-SA.
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