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The role of ceramide in regulating endoplasmic reticulum function. | LitMetric

The role of ceramide in regulating endoplasmic reticulum function.

Biochim Biophys Acta Mol Cell Biol Lipids

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

Published: January 2020

AI Article Synopsis

Article Abstract

Sphingolipids (SLs) are an important class of membrane lipids containing a long chain sphingoid base backbone. SL synthesis is compartmentalized between two major cell organelles, the endoplasmic reticulum (ER) and the Golgi apparatus. The initial steps of sphingolipid synthesis take place in the ER, where the simplest SL, ceramide, is synthesized. Although ceramide is a critical membrane component, an imbalance of ceramide levels can have significant deleterious effects on cell properties leading to events such as apoptosis. For this reason and others, ER ceramide levels must be tightly regulated. Here, we describe the biological and biophysical properties of ceramide and discuss how this might impact the ER membrane. This article is part of a special issue entitled: ER Platforms for Membrane Lipid Dynamics.

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Source
http://dx.doi.org/10.1016/j.bbalip.2019.06.015DOI Listing

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