Acoustic properties of biological tissues usually vary inhomogeneously in space. Tissues with different chemical composition often have different acoustic properties. The assumption of acoustic homogeneity may lead to blurred details, misalignment of targets and artifacts in the reconstructed photoacoustic tomography (PAT) images. This paper summarizes the main solutions to PAT imaging of acoustically heterogeneous tissues, including the variable sound speed and acoustic attenuation. The advantages and limits of the methods are discussed and the possible future development is prospected.
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http://dx.doi.org/10.7507/1001-5515.201809014 | DOI Listing |
Alzheimers Dement (Amst)
January 2025
Department of Psychiatry Rambam Health Care Campus Haifa Israel.
Background: Late-life depression (LLD) is a heterogenous disorder related to cognitive decline and neurodegenerative processes, raising a need for the development of novel biomarkers. We sought to provide preliminary evidence for acoustic speech signatures sensitive to LLD and their relationship to depressive dimensions.
Methods: Forty patients (24 female, aged 65-82 years) were assessed with the Geriatric Depression Scale (GDS).
Ecol Appl
January 2025
Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Fire shapes biodiversity in many forested ecosystems, but historical management practices and anthropogenic climate change have led to larger, more severe fires that threaten many animal species where such disturbances do not occur naturally. As predators, owls can play important ecological roles in biological communities, but how changing fire regimes affect individual species and species assemblages is largely unknown. Here, we examined the impact of fire severity, history, and configuration over the past 35 years on an assemblage of six forest owl species in the Sierra Nevada, California, using ecosystem-scale passive acoustic monitoring.
View Article and Find Full Text PDFAnal Chem
January 2025
Department of Biomedical Engineering, Lund University, Lund SE-223 63, Sweden.
Isolation and characterization of circulating tumor cells (CTCs) present a noninvasive alternative to monitor disease progression in individual patients. However, the heterogeneous lineage specificity of CTCs makes it difficult to isolate and identify possible CTCs by a liquid biopsy. Better label-free methods for the isolation of viable CTCs are needed.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
CNRS, Univ. Bordeaux, CRPP, UMR 5031, Pessac, F-33600, France.
Three-dimensional multicellular aggregates (MCAs) like organoids and spheroids have become essential tools to study the biological mechanisms involved in the progression of diseases. In cancer research, they are now widely used as in vitro models for drug testing. However, their analysis still relies on tedious manual procedures, which hinders their routine use in large-scale biological assays.
View Article and Find Full Text PDFThe cochlear nuclear complex (CN), the starting point for all central auditory processing, encompasses a suite of neuronal cell types highly specialized for neural coding of acoustic signals. However, the molecular logic governing these specializations remains unknown. By combining single-nucleus RNA sequencing and Patch-seq analysis, we reveal a set of transcriptionally distinct cell populations encompassing all previously observed types and discover multiple hitherto unknown subtypes with anatomical and physiological identity.
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