AI Article Synopsis
- A 60-year-old woman experienced severe constipation, lower limb weakness, and sensory disturbances, which were linked to combined central and peripheral demyelination.
- Her condition improved with steroid therapy and plasmapheresis, and a specific antibody (anti-lactosylceramide) was found in her serum.
- Two months post-treatment, she had a relapse that responded to steroids, and nerve conduction studies revealed reversible conduction failure during both episodes.
Article Abstract
We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566138 | PMC |
| http://dx.doi.org/10.3389/fneur.2019.00600 | DOI Listing |
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