Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous fungal infection caused by certain dematiaceous fungi (usually Fonsecaea, Phialophora, or Cladophialophora). Histologically, CBM is characterized by the presence of medlar bodies. However, the diagnosis is difficult because of the rarity of these pathognomonic presentations and the wide variety of presentations. Treatment of these infections is challenging as it lacks standardization. Herein, we report a case of chromoblastomycosis caused by Phialophora, in a 42-year-old immunocompetent male agriculturist from the humid and subtropical region of southern China. He had a 3-month history of pneumonia with intermittent fever, coughing, and expectoration. The infection subsequently spread to the bone and lymph nodes forming deep lesions and eventually resulting in osteolysis and lymphadenectasis. These subcutaneous nodules were observed after 9 months. Antifungal treatment was administered for 20 months leading to clinical improvement before the patient was lost to follow-up. This case is unique because such deep lesions are rare in immunocompetent individuals and because the initial onset was associated with pneumonia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jiac.2019.05.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Posaconazole effectiveness in rare invasive fungal infections: A systematic literature review.
Int J Antimicrob Agents
February 2025
OPEN Health, Bethesda, MD, USA.
Introduction: Mucormycosis, hyalohyphomycosis, chromoblastomycosis, and fungal mycetoma are rare invasive fungal infections (IFIs) that cause significant morbidity and mortality in immunocompromised patients. Few effective treatment options are available for these IFIs.
Methods: We performed a systematic literature review of MEDLINE and Embase to identify studies published from 2005 (year of posaconazole approval) to October 22, 2022, reporting the efficacy/effectiveness of posaconazole monotherapy or combination therapy for treating mucormycosis, hyalohyphomycosis, chromoblastomycosis, and mycetoma.
When to suspect and how properly early detect and treat patients with endemic mycoses.
Mol Aspects Med
April 2025
IMMY, Norman, OK, USA; Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, the Netherlands; Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Endemic mycoses are caused by dimorphic fungi and eventually molds, as the case of implantation mycoses. In general, these diseases are acquired through trauma or inhalation of fungal elements in the environment, and less frequently by zoonotic acquisition or transmitted during organ transplantation. The target population for endemic mycoses is usually represented by normal hosts with low-income and intensive outdoor activities.
View Article and Find Full Text PDFAnalysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with based on single-cell sequencing.
Open Med (Wars)
January 2025
Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University, 183 West Zhongshan Road, Guangzhou, China.
Chromoblastomycosis (CBM) is a chronic neglected fungal disease that causes serious damage to the physical and mental health of patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has garnered significant attention in the recent era for the treatment of CBM and has exhibited promising effects in several clinical case reports. We established a mice footpad infection model with and analyzed the impact of PDT treatment on the immune response of macrophages using single-cell sequencing.
View Article and Find Full Text PDFSuccessful Treatment of Chromoblastomycosis caused by Cladophialophora carrionii with Itraconazole: Clinicopathology, Susceptibility, and Molecular Identification of a Case in Northern China.
Am J Trop Med Hyg
December 2024
Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
Chromoblastomycosis (CBM), a prevalent subcutaneous mycosis in tropical and subtropical regions caused by dematiaceous fungi, often presents as refractory lesions. This case report details a 63-year-old woman from Tianjin, China, with CBM caused by Cladophialophora carrionii after plant trauma. Successful treatment with itraconazole was performed.
View Article and Find Full Text PDFDematiaceous Molds.
Infect Dis Clin North Am
March 2025
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Belfer 610, Bronx, NY 10461, USA. Electronic address:
Article Synopsis
- Dematiaceous molds are dark environmental molds found worldwide, particularly in tropical and subtropical areas, with common types including Bipolaris, Cladophialophora, Exophiala, and Alternaria.
- These molds can cause a variety of diseases in both healthy and immunocompromised individuals, leading to issues like skin infections, allergic reactions, pneumonia, and sometimes serious systemic infections.
- Treatment generally involves antifungal medications such as itraconazole, voriconazole, or posaconazole, combined with measures to address the source of infection and reduce immune suppression, while efforts are underway to enhance diagnostic methods and treatment options due to high mortality rates associated with severe cases.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!