AI Article Synopsis

  • - The thalamic dorsal lateral geniculate nucleus (dLGN) acts as a crucial relay for visual information before it reaches the primary visual cortex (V1).
  • - This study on Long Evans rats shows that the brain's overall state can significantly impact the dLGN's spontaneous activity and its ability to encode light information.
  • - Results indicate that while general light responsiveness remains consistent, specific types of light responses are enhanced during certain brain states under urethane anesthesia, emphasizing the need to consider anesthesia's effects in neuroscience research.

Article Abstract

The thalamic dorsal lateral geniculate nucleus (dLGN) serves as a gating station for the transfer of light information en route to the primary visual cortex (V1). Although the modulatory input arising from the V1 and several brainstem nuclei to the dLGN is well characterised in higher mammals, little is known about its influence on dLGN activity in rodents. Using simultaneous recordings of electrocorticogram (ECoG) and single unit neuronal activity under urethane anesthesia in Long Evans rats, we managed to show that cyclic changes in the general brain state strongly affect spontaneous activity and light encoding properties of dLGN neurons. First, we characterised several groups of dLGN cells: neurons led by ECoG, neurons in which the spike rate preceded ECoG changes and neurons co-occurring or not correlated with ECoG signal. Secondly, we verified that although the general light responsiveness of the dLGN is not influenced by the state of the brain, modulation of types of photoresponses and differences in ability to encode ambient light levels were observed. Cells responding to light in a sustained manner encoded light intensity more accurately during the cortical activation phase of urethane anesthesia. On the other hand, isoflurane anesthesia does not induce such rhythmic changes in ECoG and shuts down the spontaneous neuronal activity in the dLGN. Together, these data suggest a greater modulation of spontaneous activity and dLGN neurons function, than it was previously reported for the rodent dLGN and highlight the role of anesthesia in interpretations of findings from ongoing acute experiments.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2019.06.017DOI Listing

Publication Analysis

Top Keywords

urethane anesthesia
12
dlgn
9
modulation spontaneous
8
dorsal lateral
8
lateral geniculate
8
geniculate nucleus
8
general brain
8
brain state
8
neuronal activity
8
spontaneous activity
8

Similar Publications

Cardiovascular Function and Autonomic Regulation in Urethane Anesthetized and Conscious Mice.

Am J Physiol Regul Integr Comp Physiol

December 2024

Departments of Health and Human Physiology, Internal Medicine, and Pediatrics, University of Iowa, Iowa City, IA 52242 USA.

Urethane is widely used for its ability to induce prolonged anesthesia. Variability in previously reported cardiovascular parameters in murine models makes it challenging to definitively evaluate the cardiovascular effects of urethane anesthesia. We aimed to address these challenges, thereby advancing our understanding of urethane's effects on cardiovascular function in mice.

View Article and Find Full Text PDF
Article Synopsis
  • Pediatric thermal injuries can lead to serious long-term physical and psychological issues; this study focused on comparing bacterial nanocellulose (BNC) and polyurethane foam (PU-foam) dressings in burn treatment.
  • The prospective cohort study analyzed data from pediatric burn patients, examining factors like infection rates, hospital stay duration, and quality of life measures while accounting for differences in burn depth.
  • Results indicated that BNC dressings contributed to shorter hospital stays and fewer anesthesia procedures compared to PU-foam, with similar scar outcomes and quality of life; further research is needed to validate these benefits.
View Article and Find Full Text PDF

Spinal cord epidural stimulation (scES) is a therapeutic option that promotes functional improvements in sensory, motor, and autonomic functions following spinal cord injury (SCI). Previous scES mapping studies targeting the lower urinary tract (LUT) in rats demonstrated functional response variability based upon lumbosacral level, parameters used, extent of injury (spinally intact vs. chronic anatomically complete spinal transections), and sex.

View Article and Find Full Text PDF

[Investigation of the Biosafety of Commercially Available Natural Rubber Latex and Synthetic Polyurethane Condom Materials].

Sichuan Da Xue Xue Bao Yi Xue Ban

July 2024

/ ( 611730) Anesthesia and Surgery Center, Shangjin Nanfu Hospital/Shangjin Hospital, West China Hospital, Sichuan University, Chengdu 611730, China.

Objective: To investigate the biological safety of commercially available natural rubber latex and synthetic polyurethane condoms.

Methods: Natural rubber latex condom brands of A1 and A2 and polyurethane condom brands of B1 and B2 were purchased from large chain pharmacies in Chengdu, with three packages randomly selected for each brand. The study assessed the toxic effects of condom extracts on L-929 mouse fibroblasts according to GB/T standards.

View Article and Find Full Text PDF

Aims: To explore the role of voltage-gated calcium channels (VGCC) in 5-HT receptor agonist 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride's improvement of spinal cord injury (SCI) induced detrusor sphincter dyssynergia and the expressions of the 5-hydroxy tryptamine (5-HT) 2A receptors and VGCCs in lumbosacral cord after SCI.

Methods: Female Sprague-Dawley rats were randomized into normal control group and SCI group (N = 15 each). Cystometrogram (CMG), simultaneous CMG, and external urethral sphincter electromyography (EUS-EMG) were conducted in all groups under urethane anesthesia.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: